The CONQUER Trial - Cessation Of Nicotine, QUitting With E-cigarette Reduction

Inclusion Criteria

• Age: Adults aged 21 years and older
• Current Vaping Behavior: Daily or near-daily use (≥5 days/week or at least 20 days per month) of nicotine-containing e-cigarettes for at least the past 3 months.
• Motivation and desire to quit as determined by all of the following three assessment tools:

• Score of 4 or 5 on all 5-point Likert-type scale questions (see appendix)
• Score of 6 or 7 on Motivation To Stop Scale (MTSS) (see appendix)
• Participants must be classified in the Preparation stage of the Transtheoretical Model of behavior change (see appendix)
• Saliva Cotinine level ≥ 10 ng/ml
• Penn State Electronic Cigarette Dependence Index (PSECDI) of at least 4 and above
• Willingness to participate in the study and all study requirements
• Willingness to not use any other nicotine-containing products for the duration of the study
• Ability to attend visits and provide informed consent

Exclusion Criteria

• Mental Health Concerns with a score above the following thresholds:

• PHQ-2 score ≥ 2 (see appendix)
• GAD-2 score ≥ 2 (see appendix)
• Use of Other Tobacco or Nicotine Products:

• Use of any nicotine products except for vaping, including combustible tobacco (e.g., cigarettes) or other non-e-cigarette nicotine delivery systems within the past 30-days
• Current Substance or alcohol Use Disorder:

• Self-reported or medically diagnosed substance use disorder (excluding nicotine), unless in sustained remission (>12 months).
• Illicit drug use in the past 60 days
• Screening positive for alcohol use disorder in past year
• Medical Contraindications:

• Any serious medical condition or medication that would contraindicate participation in a behavioral cessation trial (to be defined and assessed by study physician or PI).
• Pregnant or breastfeeding
• Symptomatic cardiovascular disease
• Participation in another smoking/vaping cessation trial