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RecruitingAccepts healthy volunteersPhase 4

The Effect of NAD Supplementation on Brain Vascular Health in Aging

University of Oklahoma · with University of Pennsylvania, Oklahoma Medical Research Foundation · NCT05483465

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 60–85 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 4
Target enrollment
214
US sites recruiting
1
Study start
May 3, 2023
Record last updated
April 1, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Daily consumption of one of the forms of Vitamin B3, the Nicotinamide Riboside (NR), energizes the body and combats cellular aging. This study is designed to test whether NR can also improve brain health and memory.

Being studied: Nicotinamide riboside; Placebo

Conditions: Aging

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Age ≥60 and ≤85 years of age
  • Adequate hearing and visual acuity to participate in the examinations
  • Ability to read and write in English
  • Competence to provide informed consent.
  • Mini-Mental State Exam score ≥24

Exclusion Criteria

  • Vision or hearing impairment that would impair the ability to complete study assessments
  • Active CNS disease including multiple sclerosis, uncontrolled seizures, active brain cancer
  • Cerebrovascular accident other than TIA within 60 days prior to Visit 0
  • Major psychiatric disease, including major depression not currently controlled on medications, alcohol or drug abuse
  • Abnormal kidney function (creatinine >2mg/dL or EGFR \<30mL/min) by most recent labs within 6 months prior to Visit 0
  • Elevated liver enzymes (AST and/or ALT above x2 upper limit of normal) by most recent labs within 6 months prior to Visit 0
  • Treatment with other NAD enhancers (Nicotinamide riboside or nicotinamide mononucleotide) within 4 weeks prior to randomization.
  • Any other medical condition which, in the opinion of investigator, would render the patient inappropriate or too unstable to complete the study protocol

Recruiting US locations

  • University of Oklahoma Health Sciences Center

    Oklahoma City, OK 73117

    Site contact: Andriy Yabluchanskiy, MD, PhD · 405-271-8130 · andriy-yabluchanskiy@ouhsc.edu

Study contacts (from the official record)

  • Andriy Yabluchanskiy, MD, PhD · 405-271-7622 · andriy-yabluchanskiy@ouhsc.edu
All healthy volunteers studies in Oklahoma →
The Effect of NAD Supplementation on Brain Vascular Health in Aging (NCT05483465) | Bored Studies