Skip to content
Bored Studies
RecruitingAccepts healthy volunteers

The Effect of Simulated Burn Injury on Post Exercise Recovery in Hot Environments

University of Texas Southwestern Medical Center · with National Institute of General Medical Sciences (NIGMS) · NCT07050264

View Study & Apply (opens in a new tab)

Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–65 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
28
US sites recruiting
1
Study start
March 1, 2026
Record last updated
May 26, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Burn survivors have difficulty thermoregulating due to reduced skin blood flow and sweating responses at the grafted sites. It has been previously shown that this impaired heat dissipation results in burn survivors experiencing higher core temperatures for a given exercise/environmental exposure compared to non-burned individuals. This also holds true with the use of simulated burn injury. When an absorbent material is applied to the skin over a desired amount of body surface area, it replicates a burn injury of the same size (i.e., simulated burn injury). A question that remains unknown is if this impaired thermoregulation in burn survivors would affect post-exercise core temperature recovery, i.e., do burn survivors recover slower than non-burned individuals upon stopping exercise. To that end, the primary objective of this project is to determine the rate at which body temperature and other markers of thermoregulation recover after a bout of exercise in the heat and if this response is different in the same individual with and without simulated burn injury.

Being studied: Simulated burn injury via application of absorbent and impermeable material over 60% of the body

Conditions: Burn Injury; Body Temperature Regulation; Cardiovascular Physiology

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • 18 and 65 years of age
  • free of any significant underlying medical problems based upon a detailed medical history and physical exam, and normal resting electrocardiogram.

Exclusion Criteria

  • Known heart disease
  • other chronic medical conditions requiring regular medical therapy including cancer, diabetes, neurological diseases, and uncontrolled hypertension, etc. as well as serious abnormalities detected on routine screening.
  • Individuals who are pregnant, planning to become pregnant, or breastfeeding will be excluded, this will be confirmed in females using a urine pregnancy test.
  • Taking prescribed medications (such as beta blockers and non-dihydropyridine calcium channel blockers) or over-the-counter medications that have known influences on thermoregulatory response.
  • Current smokers, as well as individuals who regularly smoked within the past 3 years.
  • body mass index is ≥ 31 kg/m2.

Recruiting US locations

  • Institute for Exercise and Environmental Medicine - Texas Health Presbyterian Hospital Dallas

    Dallas, TX 75231

    Site contact: Erin M Harper, B.S. · 214-345-4737 · erin.harper2@utsouthwestern.edu

Study contacts (from the official record)

  • Erin M Harper, B.S. · 12143454737 · erin.harper2@utsouthwestern.edu
  • Elizabeth A Gideon, PhD · betsygideon@texashealth.org
All healthy volunteers studies in Texas →
The Effect of Simulated Burn Injury on Post Exercise Recovery in… (NCT07050264) | Bored Studies