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RecruitingAccepts healthy volunteersEarly Phase 1

The Effects of Bariatric Surgeries on Glucose Metabolism

The University of Texas Health Science Center at San Antonio · with National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · NCT02823665

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–65 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Early Phase 1
Target enrollment
200
US sites recruiting
2
Study start
July 2015
Record last updated
September 9, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is learn the effect of gastric bypass surgery and sleeve gastrectomy on glucose metabolism mediated by neural and hormonal factors initiated after eating.

Being studied: Exendin-(9-39); Atropine

Conditions: Post Bariatric Surgery; Gastric Bypass; Sleeve Gastrectomy; Hypoglycemia After Gastric Bypass

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Hypoglycemic RYGB patients with documented blood glucose level \<50 mg/dl
  • Asymptomatic individuals with bariatric surgery
  • Healthy non-surgical patients with no personal history of diabetes
  • Subjects must physically be able to come to our clinical research center Cedars-Sinai Medical Center

Exclusion Criteria

  • Active heart, lung, liver, gastrointestinal or kidney disease; unable to give informed consent; pregnancy; uncontrolled high blood pressure or high cholesterol; significant anemia (hemoglobin \<11g/dL); prisoners or institutionalized individuals; type 2 diabetes mellitis; development of any serious medical or psychiatric illness during recruitment or studies;
  • RYGB patients will be disqualified if they have gastric outlet obstruction or severe diarrhea.
  • Healthy non-surgical patients with personal history of diabetes

For administration of atropine, the following exclusions also apply:

  • History of glaucoma
  • Uncontrolled hypertension (any subjects with BP>140/90 and history of dyslipidemia
  • Taking any medication that might interact with atropine and cannot be stopped will be excluded from the study)
  • Myasthenia gravis
  • Brain pathology
  • Enlarged prostate in men

Recruiting US locations

  • Texas Diabetes Institute - University Health System

    San Antonio, TX 78207

    Site contact: Marzieh Salehi, MD · 210-567-6691 · hansisdiarte@uthscsa.edu

  • South Texas Veterans Health Care System

    San Antonio, TX 78229

    Site contact: Marzieh Salehi, MD · 210-567-6691 · salehi@uthscsa.edu

Study contacts (from the official record)

  • Marzieh Salehi, MD MS · 210-567-6691 · salehi@uthscsa.edu
  • Jennifer Foster, MSN · 210-450-8696 · fosterj6@uthscsa.edu
All healthy volunteers studies in Texas →
The Effects of Bariatric Surgeries on Glucose Metabolism (NCT02823665) | Bored Studies