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RecruitingAccepts healthy volunteersPhase 4

The Impact of GLP Medication on Colonoscopy Bowel Preparation Quality

The Cleveland Clinic · NCT07127354

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 4
Target enrollment
132
US sites recruiting
3
Study start
August 1, 2025
Record last updated
December 4, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this clinical trial is to learn how GLP-1 and GIP agonists effect bowel preparation in patients scheduled for colonoscopies. The main questions it aims to answer are:

  • Does GLP-1 and GIP agonist increase the rate of inadequate bowel preparation?
  • Does the quality of bowel preparation differ in patients who hold vs. those who continue a single dose of their GLP-1 or GIP agonist medication?
  • Are there any differences in the rates of complications gastric aspiration in patients who hold vs. continue a single dose of their GLP-1 or GIP agonist medication?

Being studied: Continue GLP/GIP

Conditions: GLP - 1; Bowel Preparation for Colonoscopy

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Adult patient (Age 18 years or older)
  • Patient scheduled for outpatient screening, surveillance, or diagnostic colonoscopy
  • Using a GLP-1 or GIP agonist at a stable dose for at least one month

Exclusion Criteria

  • Unable to provide informed consent, e.g., dementia
  • Patient refuses the USMSTF recommended bowel cleansing regimen for patients with diabetes or obesity (split-dose 4 liters polyethylene glycol + 15 mg bisacodyl the afternoon before; low residue diet 3 days before colonoscopy; clear liquid diet the day before colonoscopy)
  • Risk factors for inadequate bowel preparation besides diabetes and obesity with a likelihood ratio of 1.6 or greater:
  • Cirrhosis
  • Parkinson's disease
  • Dementia
  • Tricyclic antidepressant use
  • Opioid use
  • Gastroparesis* or suspected gastric outlet obstruction on pre-procedure imaging (*defined based on a documented 4-hour solid phase gastric emptying study or prior history of retained gastric contents during upper endoscopy)
  • Previous colorectal surgery
  • Prior history of inadequate bowel preparation

Recruiting US locations

  • Cleveland Clinic

    Cleveland, FL 44195

    Site contact: Samita Garg, M.D. · 216-444-7000 · GARGS@ccf.org

  • Cleveland Clinic

    Cleveland, FL 44195

    Site contact: Samita Garg, MD · 216-444-2386 · GARGS@ccf.org

  • Cleveland Clinic Weston

    Weston, FL 33331

    Site contact: Tilak Shah, M.D. · 877.463.2010 · SHAHT3@ccf.org

All healthy volunteers studies in Florida →
The Impact of GLP Medication on Colonoscopy Bowel Preparation Quality (NCT07127354) | Bored Studies