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The Metabolic Effects of Intermittent Fasting

University of Pittsburgh · with National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · NCT05722873

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 21–45 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
90
US sites recruiting
1
Study start
October 25, 2023
Record last updated
May 18, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Caloric restriction has beneficial metabolic effects in humans including weight loss and improvement in blood pressure and lipid levels. Intermittent fasting has emerged as a popular alternative to caloric restriction as it does not require daily adherence to a dietary protocol, but whether the benefits of fasting protocols are dependent on weight loss is not known. In this study, the investigators will explore the metabolic effects of fasting and evaluate whether these effects, including negative effects on bone metabolism, are independent of weight loss.

Being studied: Fasting arm; Weight maintenance; Counseling

Conditions: Normal and Overweight Individuals at High-risk of Diabetes

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Men and women, ages 21-45 years
  • BMI of at least 21 kg/m2 and up to and including BMI of 29 kg/m2
  • Normal thyroid function
  • Regular menses (women)
  • At least one first-degree relative with type 2 diabetes (T2D) and/or history of gestational diabetes

Exclusion Criteria

  • Any chronic diseases including hypertension and Type 2 diabetes mellitus
  • Indication for lipid-lowering therapy in non-diabetics, using the more stringent AHA guideline cutoff (LDL>190 or an estimated 10-year ASCVD risk of >7.5%)
  • Chronic medications, including oral contraceptive pills
  • Pregnant and/or breastfeeding
  • History of an eating disorder
  • 25-OH vitamin D level \< 20 ng/mL
  • Active substance abuse, including alcohol
  • Subjects with a prior history of intermittent fasting
  • The study physician feels that the subject may not be able to safely complete the protocol or may place themselves at risk by undergoing the protocol

Recruiting US locations

  • University of Pittsburgh

    Pittsburgh, PA 15213

    Site contact: Pouneh Fazeli, MD · pkfazeli@pitt.edu

Study contacts (from the official record)

  • Pouneh Fazeli, MD · 412-648-9770 · pkfazeli@pitt.edu
All weight loss studies in Pennsylvania →
The Metabolic Effects of Intermittent Fasting (NCT05722873) | Bored Studies