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RecruitingAccepts healthy volunteersEarly Phase 1

The Potential of Oxytocin to Reduce Opioid Abuse Liability and Pain Among Older Adults

University of Florida · with National Institute on Drug Abuse (NIDA) · NCT05761860

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 45–85 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Early Phase 1
Target enrollment
45
US sites recruiting
1
Study start
September 12, 2023
Record last updated
May 1, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Some research suggests that administration of oxytocin with oxycodone may reduce its abuse liability and improve its ability to reduce pain. In a 6-session laboratory study, we will be evaluating the effects of oxycodone and oxytocin (combined and separately, across sessions) on experimentally-induced pain, subjective effects, and decision-making.

Being studied: OxyCODONE 5 mg Oral Tablet; OxyCODONE 2.5 mg Oral Tablet; Placebo oxyCODONE Oral Tablet; Oxytocin Nasal Spray (48 IU); Placebo Oxytocin Nasal Spray

Conditions: Pain

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Individuals fluent in English will participate.
  • Must report some experience with opioids (e.g., oxycodone, defined as use at least once in the subject's lifetime).
  • Be within 20% of their ideal body weight.
  • Are not currently experiencing chronic pain (pain on most days during the past 3 months)
  • Have a systolic blood pressure of \<=140 and diastolic blood pressure of \<= 90, and a heart rate \<= 90 beats per minute.
  • Participants must also have a normal electrocardiogram (EKG) reading and bloodwork indicating no major health contraindications.

Exclusion Criteria

  • Significant current physical disease or major (uncontrolled) psychiatric disorder.
  • No self-reported current interest in drug abuse treatment.
  • Women who are pregnant or nursing.
  • Any severe comorbid illicit substance use disorders or current clinically significant withdrawal for any abused drug excluding nicotine and caffeine.

Recruiting US locations

  • University of Florida

    Gainesville, FL 32611

    Site contact: Lauren E Nieder, MSPH · 352-294-1067 · lauren.nieder@ufl.edu

Study contacts (from the official record)

  • Lauren E Nieder, MSPH · (352) 294-1067 · lauren.nieder@ufl.edu
All healthy volunteers studies in Florida →
The Potential of Oxytocin to Reduce Opioid Abuse Liability and… (NCT05761860) | Bored Studies