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The Role of Macrophage Activation in Lung Injury Following Ozone Exposure

Rutgers, The State University of New Jersey · with National Institute of Environmental Health Sciences (NIEHS) · NCT05794087

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–40 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
120
US sites recruiting
1
Study start
February 7, 2023
Record last updated
December 17, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of the study is to better understand the mechanisms of lung injury from ozone exposure. Subjects will participate in two exposure sessions: filtered air and 0.2 ppm ozone. The exposure visits will be at least 2 weeks apart. Subjects will be asked to produce sputum through coughing after each exposure. The samples will be analyzed for macrophage activity.

Being studied: Clean Air; Ozone

Conditions: Air Pollution

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Exclusion Criteria

  • Cardiovascular disease
  • Respiratory disease
  • Recent (within 4 weeks) respiratory or COVID-19 symptoms
  • Diabetes
  • Pregnancy
  • HIV Infection
  • History of smoking within the past 5 years.
  • Orthopedic or rheumatologic conditions which would interfere with cycle use
  • Inability to produce a sputum plug at screening
  • Daily use of antioxidant supplements, excluding those in a multivitamin. These supplements include Vitamin C or E, selenium, beta-carotene, lycopene, lutein, zeaxanthin and ginkgo biloba. Supplements taken less frequently but at least once a week will be reviewed by the principal investigator for eligibility determination.

Recruiting US locations

  • Rutgers - EOHSI

    Piscataway, NJ 08854

    Site contact: Kathy Black, PhD · 848-445-6049 · kgblack@eohsi.rutgers.edu

Study contacts (from the official record)

  • Kathleen Black, PhD · 8484456049 · kgblack@eohsi.rutgers.edu
  • Adriana De Resende · 848-445-0178 · ad998@eohsi.rutgers.edu
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The Role of Macrophage Activation in Lung Injury Following Ozone… (NCT05794087) | Bored Studies