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The Venous Distension Reflex and Orthostatic Hypertension

Milton S. Hershey Medical Center · NCT03496792

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
30
US sites recruiting
1
Study start
March 10, 2020
Record last updated
July 9, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This research is being done to find out whether distension of veins in legs will cause a rise in blood pressure (orthostatic hypertension).

Being studied: Tilt + external pressure; Tilt + no external pressure.; Limb occlusion + negative pressure; Limb occlusion + no negative pressure

Conditions: Blood Pressure

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Are capable of giving informed consent
  • Are of any race or ethnicity
  • Are fluent in written and spoken English
  • Whose history and physical exam did not uncover any exclusion criteria
  • Are 18 years of age

For subjects with elevated standing BP

  • Systolic BP (SBP) during standing is at least 10 mmHg > the supine SBP
  • Patients with a diagnosis of stage I hypertension without other chronic diseases may be INCLUDED

For normal subjects without elevated standing BP

  • The change in SBP by standing is within ± 5 mmHg from the supine SBP
  • Matched gender, similar age and BMI (within 10%) to participants with elevated standing BP
  • Free of acute or chronic medical conditions

Exclusion Criteria

  • Age \< 18 years of age
  • Are a pregnant or nursing woman
  • Are a prisoner or institutionalized individual or unable to consent
  • Have chronic diseases (e.g. heart, lung, neuromuscular disease, or cancer) other than stage I hypertension
  • Have orthostatic hypotension or a history of syncope
  • Current smoker
  • History of blood clots

Recruiting US locations

  • Penn State Milton S. Hershey Medical Center

    Hershey, PA 17033

    Site contact: Kristen Gray · 7175314589 · kgray1@pennstatehealth.psu.edu

Study contacts (from the official record)

  • Jian Cui, PhD · 717-531-1799 · jcui@pennstatehealth.psu.edu
  • Kris Gray · 717-531-4589 · kgray1@pennstatehealth.psu.edu
All heart & blood pressure studies in Pennsylvania →
The Venous Distension Reflex and Orthostatic Hypertension (NCT03496792) | Bored Studies