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Thermoacoustic Method for Estimating Liver Fat Fraction

Endra Lifesciences · NCT07321925

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
49
US sites recruiting
1
Study start
August 15, 2025
Record last updated
January 7, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this study is to use our Thermoacoustic Enhanced Ultrasound device to measure the fat levels in your liver and compare it to the the gold standard MRI PDFF measurements. Participants will have a scan with our device, then they will go have an abdominal MRI completed. The goal is to create a more accessible device to measure liver fat as it is an indicator for overall health and metabolic diseases.

Being studied: Thermoacoustic Enhanced Ultrasound

Conditions: MASLD/MASH (Metabolic Dysfunction-Associated Steatotic Liver Disease / Metabolic Dysfunction-Associated Steatohepatitis); Fatty Liver Disease, Nonalcoholic

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Study participants are 18 or older.
  • Able to understand, read, and provide written informed consent in English.
  • Able to tolerate both ultrasound and MRI examinations.
  • Able to lie flat, or on their side, for 20 minutes and pause breathing for up to 10 seconds.

Exclusion Criteria

  • Metal or electronic implants, including, but not limited to: pacemakers, metal clips, drug delivery pumps, hip implants, and neural stimulation devices, contraindicates for MRI.
  • Known pregnancy the day of consent or becoming pregnant during study participation based on start date of last menstrual period).
  • Liver diseases other than MASLD/MASH/fibrosis including, but not limited to:
  • Cirrhosis
  • Hepatocellular carcinoma
  • Ascites
  • Patients with broken, or injured skin, in the right upper abdominal quadrant.
  • Body habitus, or anatomical variation, where the liver capsule is not accessible with ultrasound through the patient's right intercostal imaging window used in conventional ultrasound liver imaging.
  • BMI greater than 50 kg/m2
  • Patients with subcutaneous fat at measurement location less than or equal to 6mm.
  • Patients with a missing liver lobe.
  • Patients with peri-hepatic fat in the measurement location.
  • Patients with focal liver lesions or anatomical structures in the measurement location, as detected by ultrasound.

Recruiting US locations

  • ENDRA Life Sciences

    Ann Arbor, MI 48105

    Site contact: Ava Ohlgren · 734-210-0129 · aohlgren@endrainc.com

Study contacts (from the official record)

  • Ziad Rouag · 415-531-4647 · zrouag@endrainc.com
  • Ava Ohlgren · 734-315-0090 · aohlgren@endrainc.com
All nutrition & metabolism studies in Michigan →
Thermoacoustic Method for Estimating Liver Fat Fraction (NCT07321925) | Bored Studies