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Time-Efficient Inspiratory Muscle Strength Training for Reducing Sympathetic Activity and Improving Sleep in Midlife Women

Mayo Clinic · with National Institute on Aging (NIA) · NCT06743269

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 45–60 · Women only
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
30
US sites recruiting
1
Study start
March 27, 2025
Record last updated
July 9, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this research is to understand how training the muscles used for breathing (inhalation) affects menopausal hot flashes, sympathetic nerve activity and sleep.

Being studied: High-Resistance Inspiratory Muscle Strength Training; Low-Resistance Inspiratory Muscle Strength Training; POWERbreathe K3 device

Conditions: Menopause; Hot Flashes; Blood Pressure Regulation

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Females aged 45-60 with hot flashes.
  • Participants will be recruited from Rochester, MN and surrounding areas.
  • Non-smokers.
  • BMI \< 40kg/m\^2.
  • No history of cardiovascular disease, except for hypertension.

Exclusion Criteria

  • Detailed medical and social histories will be collected. To allow for ecological validity, participants will not be excluded for use of menopausal hormone therapy or medications affecting cardiovascular function so long as they have been on a consistent regimen for ≥3 months and during the study period. This approach to medications is consistent with recent work in this area.
  • Participants will be screened for contraindications to inspiratory muscle strength training including, a history of spontaneous pneumothorax, collapsed lung that has not healed fully, a perforated eardrum that has not healed fully, and/or any other condition of the eardrum.
  • Additional exclusion criteria will include the use of sleep aids (i.e., prescription, melatonin, doxylamine, valerian root, etc.).

Recruiting US locations

Study contacts (from the official record)

  • Pamela Engrav · (507) 255-6938 · engrav.pamela@mayo.edu
  • Nancy Meyer · 507-255-0913 · meyer.nancy2@mayo.edu
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Time-Efficient Inspiratory Muscle Strength Training for Reducing… (NCT06743269) | Bored Studies