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Timing of Opioid Administration and Postoperative Respiratory Depression.

Wayne State University · NCT07227389

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–85 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
52
US sites recruiting
1
Study start
February 1, 2026
Record last updated
July 16, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this study is to determine if a relationship can be detected between the administration of an opioid and quantitative respiratory depression in spontaneously breathing non-intubated patients who have undergone general anesthesia and have received perioperative opioids.

The primary aim is to determine the temporal effect of opioid administration on respiratory depression as assessed by minute ventilation with a reduction of at least 20% in the percent of predicted minute ventilation.

A secondary aim is to determine a dose response of opioid administration and its effect on minute ventilation.

The investigators aim to determine the influence of opioid administration on minute ventilation on spontaneously breathing patients during post-anesthesia care unit (PACU) stay.

Being studied: Respiratory volume monitoring

Conditions: Respiratory Complications; Opioid Induced Respiratory Depression; Postoperative Respiratory Complications

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Written informed consent
  • Adults ≥18 years of age and ≤85 years of age
  • Patients planned for general anesthesia with an expected anesthetic time of at least 2 hours
  • Patients expected to receive postoperative opioid analgesia

Exclusion Criteria

  • Non-operative procedure (imaging)
  • Patients not admitted to the PACU postoperatively
  • Use of patient-controlled analgesia systems
  • Female patients who are pregnant or breastfeeding
  • Patients with asymmetric lung disease
  • American Society of Anesthesiologists (ASA) classification V
  • Emergency surgery (ASA E Modifier)

Recruiting US locations

  • Detroit Medical Center

    Detroit, MI 48201

    Site contact: George McKelvey M Clinical Co-ordinator, PhD · 3135986036 · George.McKelvey@northstaranesthesia.com

Study contacts (from the official record)

  • George M McKelvey, PhD · 3135986036 · George.McKelvey@northstaranesthesia.com
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