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Tracking Early Emergence of Sound Perception Impairments in FXS With Multimodal fNIRS/EEG-Preschool Age

Children's Hospital Medical Center, Cincinnati · NCT05957549

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 2–4 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
90
US sites recruiting
1
Study start
October 4, 2022
Record last updated
July 10, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Individuals with Fragile X Syndrome show differences in how they understand and learn language from infancy. They frequently have lifelong delays in speech and language as well. In addition, they experience other auditory symptoms, including being very sensitive to certain sounds as well as being more sensitive than others to loud sounds. The underlying brain activity for sound perception and speech learning in Fragile X is not well understood, especially in the infant, toddler, and preschool years. This study uses behavioral assessment of speech and language abilities, neuroimaging, and hearing tests to understand how speech and hearing are different in children with Fragile X Syndrome.

Being studied: Speech discrimination

Conditions: Fragile X Syndrome

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Diagnoses of Fragile X Syndrome, Typical Development, or History of Premature Birth
  • able to sit independently
  • English is spoken at home

Exclusion Criteria

  • For all participants: no seizures in the past 6 months
  • For typical development group and Fragile X group: not born prior to 32 weeks gestation

Recruiting US locations

  • Cincinnati Children'S Hospital

    Cincinnati, OH 45229

    Site contact: Elizabeth Smith, PhD · 513-517-1383 · elizabeth.smith3@cchmc.org

Study contacts (from the official record)

  • Elizabeth Smith, PhD · 5135171383 · elizabeth.smith3@cchmc.org
  • Craig Erickson, MD · 5136366553 · craig.erickson@cchmc.org
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Tracking Early Emergence of Sound Perception Impairments in FXS… (NCT05957549) | Bored Studies