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UAB Alzheimer's Disease Center Core Cohort - Tau Imaging Substudy

University of Alabama at Birmingham · with National Institute on Aging (NIA) · NCT03809351

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 50+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 1
Target enrollment
160
US sites recruiting
1
Study start
July 8, 2020
Record last updated
August 12, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The primary objective of this study is to measure the concentration and the regional brain distribution of pathologic tau deposition using the PET tracer AV-1451 in participants in the UAB-ADC cohort. The amount and distribution of AV-1451 in the brain will be correlated to demographic, clinical, genetic, and biospecimen data acquired through the separate ongoing UAB-ADC study. Assessment of interactions between race and vascular risk factors, brain tau levels measured with AV-1451-PET, and cognitive status will be the primary outcome of this imaging study. Individuals participating in this AV-1451-PET/MRI study will also be enrolled in an ongoing [C-11]PiB-PET/MRI study (IRB-300001005, IND-138128), and their amyloid, tau and cognitive statuses will be compared in terms of race and vascular risk factors.

Being studied: [F-18]AV-1451-PET

Conditions: Alzheimer Disease

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Enrollment in the UAB-ADC study under a separate IRB-approved research protocol.
  • Enrollment in the UAB-ADC amyloid-PET substudy under a separate IRB-approved research protocol. The amyloid-PET study does not have to have been completed prior to enrollment and participation in this tau-PET study.
  • Negative urine or serum hCG test within 2 days of [F-18]AV-1451 administration in women of child bearing potential. Women who are post-menopausal with at least 1 year since last menses or documented surgical sterilization will not require pregnancy testing.

Exclusion Criteria

  • Meets any exclusion criteria for the UAB-ADC study.
  • Inability or contraindication for undergoing MRI and/or PET imaging
  • Inability to participate in the imaging studies due to severity of dementia

Recruiting US locations

  • UAB

    Birmingham, AL 35233

    Site contact: April Riddle · 2059346504 · ariddle@uabmc.edu

Study contacts (from the official record)

  • Chinara Dosse · (205) 934-4501 · cdosse@uabmc.edu
  • Carol Chambless · (205) 975-9569 · cchambless@uabmc.edu
All neurology studies in Alabama →
UAB Alzheimer's Disease Center Core Cohort - Tau Imaging Substudy (NCT03809351) | Bored Studies