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Urine Prostate Screening Integrated With MRI for Early Detection of Prostate Cancer, UPRISE Trial

University of Michigan Rogel Cancer Center · with National Institutes of Health (NIH), National Cancer Institute (NCI) · NCT07526545

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 50–75 · Men only
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
800
US sites recruiting
1
Study start
December 1, 2026
Record last updated
October 15, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This clinical trial tests how well a urine prostate cancer screening test, My Prostate Score 2 (MPS2), integrated with magnetic resonance imaging (MRI) works for early detection of prostate cancer. MPS2 is an investigational urine-based test designed to help identify the likelihood of having aggressive prostate cancer. MPS2 testing works by measuring specific early detection biomarkers that include genetic information. This next-generation test aims to address a major challenge in prostate cancer care-detecting only the cancers that truly need treatment. Results may lead to paradigm shifts in early detection algorithms and reduce reliance on MRI and biopsy.

Being studied: Biopsy Procedure; Diagnostic Procedure; Electronic Health Record Review; Magnetic Resonance Imaging

Conditions: Prostate Carcinoma

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Males aged 50-75
  • PSA 3-20 ng/ml within the previous 3 months
  • Fit to undergo all procedures listed in protocol per treating physician's discretion
  • No prostate biopsy in the past 4 years
  • No prostate MRI in the past 2 years
  • Able to provide written informed consent

Exclusion Criteria

  • Prior diagnosis of prostate cancer
  • Contraindication to MRI (e.g. claustrophobia, pacemaker)
  • Contraindication to prostate biopsy
  • Previous hip replacement surgery, metallic hip replacement or extensive pelvic orthopaedic metal work

Recruiting US locations

  • University of Michigan Rogel Cancer Center

    Ann Arbor, MI 48109

    Site contact: Uprise StudyTeam · 734-615-6662 · uprise-spore@med.umich.edu

Study contacts (from the official record)

  • Uprise StudyTeam · 734-615-6662 · uprise-spore@med.umich.edu
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Urine Prostate Screening Integrated With MRI for Early Detection… (NCT07526545) | Bored Studies