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Using Near-Infrared Light to Better Understand Peripheral Artery Disease

The University of Texas at Arlington · NCT07313410

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
120
US sites recruiting
1
Study start
November 1, 2025
Record last updated
January 2, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this study is to better understand how blood flows and how oxygen is utilized in the lower limbs of people who suffer from peripheral artery disease. This study will also assess how these factors affect treatment outcomes.

Specific aims include

Aim 1: Utilize BB-NIR-DCS to differentiate PAD patients experiencing primary oxygen delivery limitations from those suffering from mitochondrial dysfunction.

Aim 2: Test the efficacy of BB-NIR-DCS at predicting individual responses to vascular intervention.

Conditions: Peripheral Artery Disease (PAD)

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Cases, Aim 1
  • 18 or older
  • willing to participate under the conditions described in the informed consent form (ICF)
  • eligible to sign the ICF
  • established diagnosis of PAD confirmed by a physician
  • able to comply with the study requirements
  • Cases, Aim 2
  • completed Aim 1
  • Controls 1) asymptomatic, with no history or diagnosis of peripheral artery disease

Exclusion Criteria

  • Cases, Aim 1
  • Ankle-Brachial Index >0.9 or \<0.4
  • isolated disease in aorta/iliac vessels
  • unstable angina or myocardial infarction in past 12 months
  • orthopedic or other physical limitations which would prevent data collection
  • contraindications to MRI, including presence of a Pacemaker, presence of bone growth/ bone fusion stimulators, presence of tissue expander, presence of cochlear implants, unable to ambulate for 10 feet, receiving continuous Oxygen therapy, pregnancy, permanent Jewelry (screened using MRI safety screening form and verbal screening by MRI operator
  • Cases, Aim 2
  • unstable angina or myocardial infarction in past 12 months
  • orthopedic or other physical limitations which would prevent data collection
  • contraindications to MRI, including presence of a pacemaker, presence of bone growth/ bone fusion stimulators, presence of tissue expander, presence of cochlear implants, unable to ambulate for 10 feet, receiving continuous Oxygen therapy, pregnancy, permanent Jewelry (screened using MRI safety screening form and verbal screening by MRI operator).
  • Controls 1) history of peripheral artery disease 2) overt cardiovascular disease (e.g. heart failure) 3) known pulmonary disease (excluding mild asthma) 4) current tobacco use 5) orthopedic or other physical limitations which would prevent data collection, 6) BP >150/90 mmHg at screening 7) contraindications to MRI, including presence of a pacemaker, presence of bone growth/ bone fusion stimulators, presence of tissue expander, presence of cochlear implants, unable to ambulate for 10 feet, receiving continuous Oxygen therapy, pregnancy, permanent Jewelry (screened using MRI safety screening form and verbal screening by MRI operator).

Recruiting US locations

  • University of Texas at Arlington

    Arlington, TX 76010

    Site contact: Rajvi Shah · 2147557

Study contacts (from the official record)

  • Michael Nelson, PhD · 8175130383 · michael.nelson3@uta.edu
  • Rajvi Shah, MPH · 2147557343 · rajvi.shah@uta.edu
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Using Near-Infrared Light to Better Understand Peripheral Artery… (NCT07313410) | Bored Studies