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Vaping and Smoking Withdrawal Project

State University of New York at Buffalo · with Roswell Park Cancer Institute, National Institute on Drug Abuse (NIDA) · NCT05772845

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 21–50 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
370
US sites recruiting
1
Study start
February 14, 2023
Record last updated
March 9, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The proposed research, which will systematically and comprehensively characterize the withdrawal among daily vapers compared to daily smokers of combustible cigarettes, filling critical gaps in the understanding of electronic nicotine delivery systems (ENDS) dependence/abuse liability and contributing to the development of therapies for tobacco/nicotine use, the leading preventable cause of death in the US.

Being studied: Acute (24-hour) abstinence; Ad libitum smoking/vaping

Conditions: Acute Abstinence From Cigarettes vs E-cigarettes (ENDS)

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • 6+ months of daily/near-daily nicotine vaping and/or cigarette smoking (to yield 160 vapers, 160 smokers, 50 dual users)
  • 200+ ng/mL cotinine on a commercially-available quick screen

Current Exclusion Criteria

  • intention to quit daily/near-daily vaping/smoking in the next month
  • current (2+ days out of the past 7) use of pipe tobacco, hookah/shisha, smokeless tobacco, dissolvable tobacco, nicotine pouches. For vaping group only, current (2+ days out of past 7) use of cigars, cigarillos, or filtered cigars that are filled with tobacco or a mix of tobacco and marijuana
  • current use of any smoking cessation medication
  • current severe substance dependence other than tobacco/nicotine (including cannabis; NIDA Modified ASSIST of 27+)
  • current (past 2 weeks) suicidal ideation with intent and/or plan
  • current antipsychotic medications or lifetime history of schizophrenia or bipolar disorder
  • pregnancy (intake urine screen)

Original Exclusion Criteria that have been modified or eliminated:

  • >1 use in past month of tobacco/nicotine products other than ENDS and combustible cigarettes (modified 5/19/25 - see current exclusion criteria)
  • alcohol: AUDIT > 15 for males and >13 for females (eliminated 7/25/23)
  • current major depression (PHQ-9>11) (eliminated 7/25/23)
  • suicide risk (answer to question #9 on PHQ-9 is anything other than "Not at all") (modified 11/17/23 - see current exclusion criteria)

Recruiting US locations

  • University at Buffalo

    Buffalo, NY 14260

    Site contact: Larry Hawk, PhD · 7166450192 · lhawk@buffalo.edu

Study contacts (from the official record)

  • Larry Hawk, PhD · 716-645-0192 · lhawk@buffalo.edu
All smoking & vaping studies in New York →
Vaping and Smoking Withdrawal Project (NCT05772845) | Bored Studies