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Vascular Function and Oxidative Stress in Emergency Medical Responders

University of Delaware · NCT06985394

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 20–40 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
45
US sites recruiting
1
Study start
May 14, 2025
Record last updated
May 22, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this clinical trial is to characterize blood vessel function and oxidative stress (a harmful condition that damages cells and tissues) in emergency medical technicians (EMTs). The main questions it aims to answer are:

  • Does an overnight shift work in emergency medical technicians reduce blood vessel function and increase oxidative stress?
  • Can supplementing with antioxidants help reduce the negative effects of night shift work in emergency medical technicians?

Researchers will compare antioxidants to a placebo (a look-alike substance that contains no drug) to see if antioxidants work in reducing the negative effects of night shift work in emergency medical technicians.

Participants will

  • Report to the lab two separate times following an overnight shift to assess blood vessel functioning and oxidative stress 3. Take an antioxidant supplement or placebo during each night of shift work.

Being studied: Antioxidant cocktail; Placebo

Conditions: Cardiovascular Function in EMTs

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Body mass index between 18.5 and \<35 kg/m²
  • Seated resting systolic blood pressure \< 140 mmHg, and seated resting diastolic blood pressure \< 90 mmHg
  • Participant must be an active first responder that works shift work schedules. e.g., emergency medical responders, basic life support emergency medical technicians (i.e., BLS EMT), advanced life support emergency medical technicians (A-EMT), and paramedics
  • Participant must have been working shift work for at least 1 year
  • Participant must work at least 4 night shifts per month

Exclusion Criteria

  • Participant is unwilling or unable to give consent
  • Participant has been diagnosed with any chronic disease (a history of high blood pressure, heart disease, diabetes, cancer, kidney disease)
  • Participant has been diagnosed with a sleep disorder (e.g., insomnia, restless leg syndrome, sleep apnea)
  • Participant is currently taking melatonin or other sleep aids (e.g., Ambien, sedatives, etc.), or any supplements/medications known to alter sleep patterns. Participants using melatonin must undergo a minimum 72-hour washout period prior to study participation to ensure baseline sleep patterns are not affected[15, 16]
  • Resting blood pressure >140/90 mmHg
  • Body mass index \<18.5 or >35 kg/m2
  • Currently pregnant or breast feeding (women only)
  • Currently use tobacco or nicotine products (≥1 cigarette, cigar, e-cigarette, vape, or any other nicotine-containing product in the last month), including smokeless tobacco (e.g., chewing tobacco, snuff, dip, snus), nicotine lozenges or gum, heated tobacco products, and any illicit drugs

Recruiting US locations

  • University of Delaware

    Newark, DE 19713

    Site contact: Alexs Matias, MS · 914-523-1953 · amatias@udel.edu

Study contacts (from the official record)

  • Alexs Matias, MS · 914-523-1953 · amatias@udel.edu
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