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WISE-2B Brain Study (Weight Loss Intervention Surgical Effects on Brain Function)

University of Florida · with National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) · NCT06861790

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 20–75 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
120
US sites recruiting
1
Study start
November 10, 2025
Record last updated
February 10, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of the study to understand the effects of weight loss and improvements in diabetes following bariatric surgery on brain function and thinking. This study will also examine whether non-invasive transcutaneous vagal nerve stimulation (tVNS) intervention initiated 30 days post-surgery improves brain function and thinking. The study does NOT cover any costs associated with bariatric surgery.

Being studied: tVNS; Complete Vagotomy; Anterior Vagotomy

Conditions: Diabetes; Weight Loss

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Between age: 20-75 yrs, English speaking, Physically mobile
  • Body Mass Index (BMI) >35 kg before surgery
  • Compatible of MRI Scanning
  • Willing to give a small blood sample
  • Capable of providing informed consent

Exclusion Criteria

  • Prior or current neurological disorder
  • Major psychiatric disturbance
  • Unstable medical conditions (cancer)
  • MRI contraindications (claustrophobia, metal implants, waist/torso circumference)

Recruiting US locations

  • University of Florida - College of Public Health and Health Professions

    Gainesville, FL 32611

    Site contact: Keyanni Johnson · 352-294-5816 · kjjohnson@ufl.edu

Study contacts (from the official record)

  • Keyanni J Johnson · 3522945618 · kjjohnson@ufl.edu
  • Ronald Cohen, PhD · 352-295-5840 · roncohen@ufl.edu
All weight loss studies in Florida →
WISE-2B Brain Study (Weight Loss Intervention Surgical Effects on… (NCT06861790) | Bored Studies