Phase 1 · Bethesda, MD
Phase 1 clinical trials in Bethesda, MD
37 recruiting studies have a site in Bethesda.
37 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1Overnight stay mentioned
Role of Metal Ion Transporter ZIP8 in Alcohol-Related Behaviors
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 21–60
- RecruitingHealthy volunteersPhase 1Overnight stay mentioned
Study of Intravenous ZMA001 in Healthy Subjects
National Heart, Lung, and Blood Institute (NHLBI)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersEarly Phase 1
Study Brain Mechanisms of Frustration With Magnetoencephalography in Healthy Volunteers
National Institute of Mental Health (NIMH)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
Evaluating the Dose, Safety, Tolerability, and Immunogenicity of Mosaic Hexavalent Influenza Vaccine VRCFLUMOS0116-00-VP (FluMos-v2) With and Without ALFQ Adjuvant in Healthy Adults
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–50
- RecruitingHealthy volunteersPhase 1
PET Imaging of Phosphodiesterase-4 (PDE4) in Volunteers With Alzheimer Disease (AD) or Mild Cognitive Impairment (MCI)
National Institute of Mental Health (NIMH)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 50–100
- RecruitingHealthy volunteersPhase 1
First-in-Human Evaluation of [11C]JMJ-129-d2 for PDE4D Imaging in Healthy Volunteers
National Institute of Mental Health (NIMH)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–105
- RecruitingHealthy volunteersPhase 1
Phase 1 Challenge Study Using rDEN2delta30-7169 to Evaluate Host-Pathogen Interactions in Primary, Homotypic, and Heterotypic Dengue Virus Infection
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–50
- RecruitingHealthy volunteersPhase 1
Neuropharmacologic Imaging and Biomarker Assessments of Response to Acute and Repeated-Dosed Ketamine Infusions in Major Depressive Disorder
National Institute of Mental Health (NIMH)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–65
- RecruitingHealthy volunteersPhase 1
Imatinib to Increase RUNX1 Activity in Participants With Germline RUNX1 Deficiency
National Cancer Institute (NCI)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–120
- RecruitingHealthy volunteersPhase 1
Quadrivalent Influenza HA Stem Vaccine VRC-FLUMOS0122-00-VP (SteMos1) With and Without ALFQ Adjuvant in Healthy Adults
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–50
- RecruitingHealthy volunteersPhase 1/Phase 2
Suvorexant for Alcohol Use Disorder (AUD): Neural Mechanisms
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1
Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of Fx-5A in Healthy Volunteers
National Heart, Lung, and Blood Institute (NHLBI)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–99
- RecruitingHealthy volunteersPhase 1/Phase 2
Phase I/II Study to Reduce Post-transplantation Cyclophosphamide Dosing for Older or Unfit Patients Undergoing Bone Marrow Transplantation for Hematologic Malignancies
National Cancer Institute (NCI)
- Location
- Bethesda, MD + 1 other US site
- Eligibility basics
- Ages 12–85
- RecruitingHealthy volunteersPhase 1/Phase 2
Donor Lymphocyte Infusion After Allogeneic Hematopoietic Cell Transplantation for High-Risk Hematologic Malignancies
National Cancer Institute (NCI)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 12–120
- RecruitingHealthy volunteersPhase 1/Phase 2
The Lowest Effective Dose of Post-Transplantation Cyclophosphamide in Combination With Sirolimus and Mycophenolate Mofetil as Graft-Versus-Host Disease Prophylaxis After Reduced Intensity Conditioning and Peripheral…
National Cancer Institute (NCI)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 12–120
- RecruitingHealthy volunteersPhase 1/Phase 2
Trial of Allogeneic Reduced-Intensity, HLA-Haploidentical Allogeneic Hematopoietic Cell Bone Marrow Transplantation Followed by Graft-versus-Host-Disease (GVHD) Prophylaxis With Cyclophosphamide, Bortezomib and…
National Cancer Institute (NCI)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 12–120
- RecruitingHealthy volunteersPhase 1/Phase 2
Safety and Immunogenicity of Recombinant Varicella Zoster Virus Vaccine in People With HIV Who Have a CD4 Count Less Than 300 or Greater Than or Equal to 300 and a Healthy Control Population
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1
Assessment of [18F]-Fluorocellobiose ([18F]FCB) Pharmacokinetics in Healthy Volunteers and Subjects With Invasive Mold Infections
National Institutes of Health Clinical Center (CC)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–100
- RecruitingHealthy volunteersPhase 1
Epstein-Barr Virus (EBV) gH/gL/gp42-Ferritin Nanoparticle Vaccine With or Without gp350-Ferritin in Healthy Adults With or Without EBV Infection
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–29
- RecruitingHealthy volunteersPhase 1
[18F]PF-06445974 to Image PDE4B in Major Depressive Disorder Using PET
National Institute of Mental Health (NIMH)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteersPhase 1
Evaluation of [11C]ZTP-1 to Image PDE4B
National Institute of Mental Health (NIMH)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–101
- RecruitingHealthy volunteersPhase 1
PET Imaging of Noradrenergic Transmission in the Brain
National Institute of Mental Health (NIMH)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–105
- RecruitingHealthy volunteersPhase 1
Nicotinic Receptor Genetic Variation and Alcohol Reward
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 21–60
- RecruitingHealthy volunteersPhase 1
Induced Blood-Stage Malaria in Healthy Malaria-Naive Adults to Assess the Safety and Infectivity of Plasmodium Vivax Challenge Agent and Evaluate Transmission in Mosquito Feeding Assays
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Bethesda, MD
- Eligibility basics
- Ages 18–54
Who these studies look for
Phase 1 studies often have narrow eligibility: specific age and weight ranges, no recent participation in another study, no nicotine, and limits on medications. Some Phase 1 studies recruit patients rather than healthy volunteers, so check each listing.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.