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A Clinical Trial of MK-4082 in Healthy Participants (MK-4082-005)

Merck Sharp & Dohme LLC · NCT07697625

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–55 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 1
Target enrollment
28
US sites recruiting
1
Study start
July 20, 2026
Record last updated
August 5, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Researchers are looking for new weight loss medicines for people with higher body weight. The trial medicine, MK-4082, is different from similar weight loss medicines because people take it as a pill instead of an injection. Before giving a trial medicine to participants with a health condition, researchers first do trials in healthy participants to find a safe dose level (amount) of the trial medicine.

The goal of this study is to learn what happens to MK-4082 in a person's body over time. Researchers will compare what happens to levels of MK-4082 in people's blood when it is taken alone (Part 1, Period 1 and Part 2) and in combination with (Part 1, Period 2) another medicine called diltiazem. Researchers also want to learn about the safety of MK-4082 taken with and without diltiazem and if people tolerate them.

Being studied: MK-4082; Diltiazem; Rescue medication

Conditions: Healthy

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

The main inclusion criteria include but are not limited to the following:

  • Is in good health
  • Body mass index (BMI) between 18 and 32 kg/m\^2, inclusive

Exclusion Criteria

The main exclusion criteria include but are not limited to the following:

  • Has a history of previous surgical treatment for obesity that may induce malabsorption, history of bowel resection >20 cm, any malabsorption disorder, severe gastroparesis, or any GI procedure for weight loss
  • Had a recent pancreatitis or has a history of pancreatitis

Recruiting US locations

  • Anaheim Clinical Trials ( Site 0001)

    Anaheim, CA 92801

    Site contact: Study Coordinator · 714-774-7777

Study contacts (from the official record)

  • Toll Free Number · 1-888-577-8839 · Trialsites@msd.com
All healthy volunteers studies in California →
A Clinical Trial of MK-4082 in Healthy Participants (MK-4082-005) (NCT07697625) | Bored Studies