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RecruitingPhase 2

A Mechanistic Study of MAR001 in Adults With Elevated Triglycerides and Remnant Cholesterol

Marea Therapeutics · NCT07199309

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–75 · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Phase 2
Target enrollment
30
US sites recruiting
1
Study start
September 26, 2025
Record last updated
November 6, 2025

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The primary objective of the study is to determine the effect of MAR001 as compared to placebo on levels of the triglycerides (TG) in the postprandial state in adults with elevated TG.

Being studied: MAR001; Placebo

Conditions: Hypertriglyceridemia

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Willingness to provide informed consent and comply with the intervention and all study assessments
  • Two fasting TG collected at two separate, consecutive visits at least 7 days apart during the Screening period
  • HbA1c ≥ 5.7% and ≤ 8.5%
  • Stable diet for a minimum of 3 months prior to screening and with no plans to change diet through duration of study
  • Stable drug regimen (appropriate if relevant) prior to screening visit and no planned changes during screening or trial participation

Exclusion Criteria

  • Acute or chronic liver disease
  • Diabetes medications (other than metformin)
  • History of type 1 diabetes mellitus or history of diabetic ketoacidosis
  • Newly diagnosed T2DM
  • Participants with known active hepatitis A, B, or C
  • Participants who are known to have uncontrolled human immunodeficiency virus (HIV) infection
  • Uncontrolled hypothyroidism
  • Any condition that prevents the participant from complying with study procedures

Recruiting US locations

Study contacts (from the official record)

  • Andrew Lane · 415-766-3610 · MAR-104-info@mareatx.com
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A Mechanistic Study of MAR001 in Adults With Elevated… (NCT07199309) | Bored Studies