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RecruitingPhase 3

A Phase III Study to Evaluate the Efficacy and Safety of Petrelintide in Participants With Overweight or Obesity

Hoffmann-La Roche · with Zealand Pharma · NCT07843498

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Phase 3
Target enrollment
3900
US sites recruiting
3
Study start
September 30, 2026
Record last updated
October 7, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study will evaluate the efficacy and safety of petrelintide compared with placebo, in conjunction with a reduced-calorie diet and increased physical activity, for weight management in participants living with overweight or obesity, at least one weight-related comorbidity, and without Type 2 Diabetes (T2D).

Being studied: Petrelintide; Placebo

Conditions: Obesity or Overweight

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Participants with BMI ≥ 30 kg/m² or BMI ≥ 27 kg/m² with at least one weight-related comorbidity
  • History of at least one self-reported unsuccessful dietary effort to lose body weight

Exclusion Criteria

  • HbA1c ≥ 48 mmol/mol (6.5%), measured by the central laboratory at screening
  • Known history of Type 1 or Type 2 diabetes mellitus
  • Current or previous treatment with petrelintide or any other amylin analog

Recruiting US locations

Study contacts (from the official record)

  • Reference Study ID Number: CC46368 https://forpatients.roche.com/No attachments to email below. · 888-662-6728 (U.S. and Canada) · global-roche-genentech-trials@gene.com
  • Fastest Response: use the inquiry form. https://www.gene.com/contact-us/submit-medical-inquiry
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A Phase III Study to Evaluate the Efficacy and Safety of… (NCT07843498) | Bored Studies