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A Prospective Longitudinal Observational Cohort Study of Pregnant Women Residing at High Altitude in Bolivia

Massachusetts General Hospital · NCT07312227

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–45 · Women only
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
27
US sites recruiting
1
Study start
February 11, 2026
Record last updated
May 26, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

In this study, the investigators will follow two small cohorts of pregnant women: a cohort of healthy women with uncomplicated pregnancies residing at high altitude, a control group of healthy women with uncomplicated pregnancies residing at sea level, to characterize differences in cardiopulmonary adaptation and nitric oxide (NO) pathway expression at elevations >3,500 m throughout pregnancy and into the postpartum period. The investigators aim to investigate right-sided cardiac impairment induced by chronic hypobaric hypoxemia, its effects on fetal growth, and the potential contribution of cardiovascular nitric oxide depletion to obstetric complications.

Conditions: Hypertensive Disorder of Pregnancy; Pulmonary Arterial Hypertension; Intrauterine Growth Restriction

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • women delivering at participating hospitals at more than 3500 meters or women delivering at participating hospitals at sea level
  • signed informed consent

Exclusion Criteria

  • preexisting cardiopulmonary pathologies (CHD, COPD, CKD, NYHA > III)

Recruiting US locations

  • Massachusetts General Hospital

    Boston, MA 02114

    Site contact: Lorenzo Berra, MD

Study contacts (from the official record)

  • Lorenzo Berra, MD · 617-726-3030 · lberra@mgh.harvard.edu
  • Andrea Bolchini, MD · 617-216-5124 · abolchini@mgh.harvard.edu
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A Prospective Longitudinal Observational Cohort Study of Pregnant… (NCT07312227) | Bored Studies