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RecruitingPhase 3

A Study Evaluating Efruxifermin in Subjects With Compensated Cirrhosis Due to NASH/MASH

Akero Therapeutics, Inc · NCT06528314

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–80 · All sexes
Healthy volunteers
Not accepted (a condition is required)
Study type
Interventional · Phase 3
Target enrollment
2150
US sites recruiting
160
Study start
October 4, 2024
Record last updated
October 13, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This is a multi-center evaluation of efruxifermin (EFX) in a randomized, double-blind, placebo-controlled study in subjects with compensated cirrhosis due to NASH/MASH.

Being studied: Efruxifermin; Placebo

Conditions: NASH - Nonalcoholic Steatohepatitis; MASH - Metabolic Dysfunction-Associated Steatohepatitis

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Cohort 1: Biopsy proven compensated cirrhosis (fibrosis stage 4) due to NASH/MASH and NAS score of >=3 (at least 1 in each category) or evidence of steatosis and 2 current features of metabolic comorbidities
  • Cohort 2: Biopsy proven or non-invasively diagnosed compensated cirrhosis (fibrosis stage 4) due to NASH/MASH

Exclusion Criteria

  • Other causes of liver disease based on medical history and/or liver histology and/or central laboratory results
  • Type 1 diabetes or unstable Type 2 diabetes
  • Any current or prior history of decompensated liver disease

Other inclusion and exclusion criteria may apply.

Recruiting US locations

  • Akero Clinical Study Site

    Birmingham, AL 35209

    Site contact: Akero Site 0129

  • Akero Clinical Study Site

    Dothan, AL 36301

    Site contact: Akero Site 0233

  • Akero Clinical Study Site

    Chandler, AZ 85224

    Site contact: Akero Site 9106

  • Akero Clinical Study Site

    Peoria, AZ 85381

    Site contact: Akero Site 9104

  • Akero Clinical Study Site

    Scottsdale, AZ 85258

    Site contact: Akero Site 0278

  • Akero Clinical Study Site

    Tucson, AZ 85712

    Site contact: Akero Site 9210

  • Akero Clinical Study Site

    Tucson, AZ 85712

    Site contact: Akero Site 9144

  • Akero Clinical Study Site

    Tucson, AZ 85713

    Site contact: Akero Site 0234

  • Akero Clinical Study Site

    Tucson, AZ 85715

    Site contact: Akero Site 0209

  • Akero Clinical Study Site

    Little Rock, AR 72205

    Site contact: Akero Site 0106

  • Akero Clinical Study Site

    North Little Rock, AR 72117

    Site contact: Akero Site 9214

  • Akero Clinical Study Site

    Coronado, CA 92118

    Site contact: Akero Site 0132

  • Akero Clinical Study Site

    Escondido, CA 92025

    Site contact: Akero Site 0266

  • Akero Clinical Study Site

    Folsom, CA 95630

    Site contact: Akero Site 0263

  • Akero Clinical Study Site

    Fountain Valley, CA 92708

    Site contact: Akero Site 1013

  • Akero Clinical Study Site

    Lancaster, CA 93534

    Site contact: Akero Site 0285

  • Akero Clinical Study Site

    Long Beach, CA 90815

    Site contact: Akero Site 0188

  • Akero Clinical Study Site

    Los Angeles, CA 90015

    Site contact: Akero Site 1019

  • Akero Clinical Study Site

    Los Angeles, CA 90048

    Site contact: Akero Site 0236

  • Akero Clinical Study Site

    Newport Beach, CA 92663

    Site contact: Akero Site 0206

  • Akero Clinical Study Site

    Orange, CA 92868

    Site contact: Akero Site 0261

  • Akero Clinical Study Site

    Pasadena, CA 91105

    Site contact: Akero Site 9250

  • Akero Clinical Study Site

    Redwood City, CA 94063

    Site contact: Akero Site 0191

  • Akero Clinical Study Site

    Sacramento, CA 95817

    Site contact: Akero Site 0274

  • Akero Clinical Study Site

    San Francisco, CA 94115

    Site contact: Akero Site 0147

  • Akero Clinical Study Site

    San Francisco, CA 94117

    Site contact: Akero Site 0269

  • Akero Clinical Study Site

    San Jose, CA 95116

    Site contact: Akero Site 0280

  • Akero Clinical Study Site

    Tarzana, CA 91356

    Site contact: Akero Site 0297

  • Akero Clinical Study Site

    Aurora, CO 80045

    Site contact: Akero Site 0217

  • Akero Clinical Study Site

    Colorado Springs, CO 80907

    Site contact: Akero Site 0260

  • Akero Clinical Study Site

    Englewood, CO 80113

    Site contact: Akero Site 9243

  • Akero Clinical Study Site

    New Haven, CT 06511

    Site contact: Akero Site 0213

  • Akero Clinical Study Site

    Washington D.C., DC 20422

    Site contact: Akero Site 0262

  • Akero Clinical Study Site

    Bradenton, FL 34208

    Site contact: Akero Site 0153

  • Akero Clinical Study Site

    Brandon, FL 33511

    Site contact: Akero Site 0222

  • Akero Clinical Study Site

    Cutler Bay, FL 33189

    Site contact: Akero Site 0251

  • Akero Clinical Study Site

    Doral, FL 33126

    Site contact: Akero Site 0267

  • Akero Clinical Study Site

    Fort Myers, FL 33912

    Site contact: Akero Site 9134

  • Akero Clinical Study Site

    Hialeah Gardens, FL 33016

    Site contact: Akero Site 9242

  • Akero Clinical Study Site

    Inverness, FL 34452

    Site contact: Akero Site 9135

  • Akero Clinical Study Site

    Lakewood Rch, FL 34211

    Site contact: Akero Site 9203

  • Akero Clinical Study Site

    Largo, FL 33777

    Site contact: Akero Site 9248

  • Akero Clinical Study Site

    Lehigh Acres, FL 33936

    Site contact: Akero Site 0271

  • Akero Clinical Study Site

    Margate, FL 33063

    Site contact: Akero Site 0248

  • Akero Clinical Study Site

    Miami, FL 33136

    Site contact: Akero Site 0137

  • Akero Clinical Study Site

    Miami, FL 33175

    Site contact: Akero Site 0252

  • Akero Clinical Study Site

    Miami Gardens, FL 33014

    Site contact: Akero Site 0243

  • Akero Clinical Study Site

    Naples, FL 34102

    Site contact: Akero Site 0138

  • Akero Clinical Study Site

    New Port Richey, FL 34653

    Site contact: Akero Site 0257

  • Akero Clinical Study Site

    Ocala, FL 34471

    Site contact: Akero Site 9127

  • Akero Clinical Study Site

    Orlando, FL 32807

    Site contact: Akero Site 0250

  • Akero Clinical Study Site

    Pembroke Pines, FL 33027

    Site contact: Akero Site 0239

  • Akero Clinical Study Site

    Riverview, FL 33578

    Site contact: Akero Site 0295

  • Akero Clinical Study Site

    Sarasota, FL 34240

    Site contact: Akero Site 9218

  • Akero Clinical Study Site

    Temple Terrace, FL 33617

    Site contact: Akero Site 0242

  • Akero Clinical Study Site

    Weston, FL 33331

    Site contact: Akero Site 0270

  • Akero Clinical Study Site

    Zephyrhills, FL 33542

    Site contact: Akero Site 0235

  • Akero Clinical Study Site

    Atlanta, GA 30309

    Site contact: Akero Site 0230

  • Akero Clinical Study Site

    Atlanta, GA 30327

    Site contact: Akero Site 1006

  • Akero Clinical Study Site

    Gainesville, GA 30501

    Site contact: Akero Site 0183

+ 100 more on the official record.

Study contacts (from the official record)

  • Akero Study Director · 650-487-6488 · AkeroSynchrony@akerotx.com
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A Study Evaluating Efruxifermin in Subjects With Compensated… (NCT06528314) | Bored Studies