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A Study to Evaluate the Impact of Lactobacillus Rhamnosus GG on Proton Pump Inhibitor-Induced Gut Dysbiosis

Mayo Clinic · NCT05517928

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
30
US sites recruiting
1
Study start
March 3, 2023
Record last updated
January 8, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of this study is to investigate the impact of the probiotic Lactobacillus rhamnosus (LGG) on proton pump inhibitor (PPI)-induced changes to the microbes that live in the gastrointestinal tract and are passed out in the stool. PPI medicines reduce stomach acid and are commonly used to treat acid reflux disease.

Being studied: Omeprazole; Lactobacillus rhamnosus GG; Placebo

Conditions: Healthy

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Individuals on an unrestricted regular diet with no dietary restrictions (vegan, low FODMAP, gluten free, dairy-free etc) or other fad diets (e.g., keto, intermittent fasting, etc.).
  • Healthy subjects will be screened for current or chronic GI symptoms using a 16-item questionnaire.
  • Only those with an absence of symptoms will eligible to participate.

Exclusion Criteria

  • For healthy volunteers, will include prior surgery altering the esophagus, stomach, and intestine (except appendectomy).
  • Chronic daily use of medications affecting GI secretion or motor function.
  • The presence of any GI-motility affecting systemic diseases or untreated psychiatric disease.
  • Pregnancy.

Recruiting US locations

  • Mayo Clinic Arizona

    Scottsdale, AZ 85259

    Site contact: Yonas Berhe, B.S · 480-301-6315 · berhe.yonas@mayo.edu

Study contacts (from the official record)

  • Alexandria Ramirez · 4805741853 · ramirez.alexandria@mayo.edu
All healthy volunteers studies in Arizona →
A Study to Evaluate the Impact of Lactobacillus Rhamnosus GG on… (NCT05517928) | Bored Studies