A Study to Evaluate Tradipitant on Treating Nausea and Vomiting Induced by GLP-1R Agonist Use
Vanda Pharmaceuticals · NCT07446439
Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.
Key facts
- Compensation
- Not posted. Ask the study team before screening.
- Who can join
- Ages 18–65 · All sexes
- Healthy volunteers
- Accepted
- Study type
- Interventional · Phase 3
- Target enrollment
- 280
- US sites recruiting
- 3
- Study start
- March 27, 2026
- Record last updated
- April 20, 2026
Status re-checked against ClinicalTrials.gov within the last 12 hours.
What the study is about
The goal of this study is to measure the effects of using Tradipitant to treat nausea and vomiting induced by GLP-1R agonist use in adults with class I or class II obesity, or adults who are overweight with at least one weight-related condition. The study is placebo-controlled with two treatment arms.
Being studied: Tradipitant; Placebo
Conditions: Nausea and Vomiting; Obesity
Eligibility criteria
Copied from the official record. The study team makes the final decision at screening.
Show full criteria
Inclusion Criteria
- Body Mass Index ≥ 25 and \< 40 kg/m\^2
- No serious medical problems or chronic diseases, specifically no type I or type II diabetes
Exclusion Criteria
- Another disorder that contributes to gastrointestinal symptoms
- History of intolerance and/or hypersensitivity to NK-1 receptor antagonists
- History of intolerance and/or hypersensitivity to GLP-1 receptor agonists
- Exposure to any investigational medication within the past 60 days
Recruiting US locations
Vanda Investigational Site
Los Angeles, CA 90025
Site contact: Vanda Pharmaceuticals · 202-734-3400
Vanda Investigational Site
San Diego, CA 92108
Site contact: Vanda Pharmaceuticals · 202-734-3400
Vanda Investigational Site
Tampa, FL 33613
Site contact: Vanda Pharmaceuticals · (202) 734-3400
Study contacts (from the official record)
- Vanda Pharmaceuticals · (202) 734-3400 · clinicaltrials@vandapharma.com
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