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A Study to Test the Diagnostic Potential of Brillouin Microscopy for Corneal Ectasia

Massachusetts General Hospital · with Harvard Medical School (HMS and HSDM) · NCT02118922

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 20–75 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
168
US sites recruiting
1
Study start
June 2013
Record last updated
October 8, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

We have developed novel Brillouin microscopy and we are testing its potential for keratoconus and ectasia diagnostics. We plan to perform axial scans of the cornea in human volunteers in order to compare biomechanical properties of Keratoconus vs. Normal corneas and compare biomechanical properties of post-LASIK ectasia vs. normal corneas.

Being studied: Brillouin imaging

Conditions: Keratoconus; Ectasia; Crosslinking; Fuchs' Endothelial Dystrophy

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

Group I includes healthy subjects with normal appearing corneas, normal topography and pachymetry. Group II includes patients diagnosed as having mild, moderate or advanced keratoconus by our ophthalmology expert on the basis of topography and pachymetry. Group III includes healthy subjects who have undergone LASIK surgery in the past 12 months without complications. Inclusion criteria include normal post-operative topography and pachymetry. Group IV includes patients (age 20 - 60) who have undergone LASIK surgery at least 12 months before the study imaging and have been diagnosed with post-LASIK ectasia based on topography, pachymetry and clinical evaluation.Patients diagnosed with keratoconus. Group V- Volunteers to receive PRK surgery This group includes patients who have been diagnosed with myopia and have been scheduled to undergo PRK surgery. Patients with high astigmatism > 2 diopter, prior ocular surgeries, and those patients taking any ocular medications except seasonal allergy medicine such as ketotifen or artificial tears will be excluded. Group VI-Volunteers to receive LASIK Surgery This group includes myopic patients who are scheduled to receive LASIK surgery. Patients with high astigmatism > 2 diopter, prior ocular surgeries, and those patients taking any ocular medications except seasonal allergy medicine such as ketotifen and artificial tears will be excluded. Group VII- Patients with Fuch's Endothelial Corneal Dystrophy. This group includes subjects who are diagnosed with Fuch's corneal dystrophy, at early, mild and advanced stages. The inclusion also extends to subjects with, and without keratoconus. But this exclude patients with any other corneal disorders other than keratoconus, and/or history of ophthalmological surgeries that may affect endothelium cell status, e.g. cataract surgeries.

Overall Exclusion Criteria for all groups: Volunteers who

  • Have occludable narrow angles (without a patent peripheral iridotomy)
  • Monocular subjects
  • Do not or cannot understand the instructions for the imaging

Recruiting US locations

  • Massachusetts General Hospital

    Boston, MA 02114

    Site contact: giuliano scarcelli, PhD · 6177688698 · scarcelli.giuliano@mgh.harvard.edu

Study contacts (from the official record)

  • Fatima Clouser, MS · 4077331679 · fclouser@mgh.harvard.edu
  • Andy Yun, PhD · syun@partners.org
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A Study to Test the Diagnostic Potential of Brillouin Microscopy… (NCT02118922) | Bored Studies