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Adipocyte-Derived Extracellular Vesicles, Weight Loss, and Endothelial Function

University of Colorado, Boulder · NCT06776081

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 40+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
84
US sites recruiting
1
Study start
July 1, 2024
Record last updated
April 28, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Changes in adipose tissue biology are now recognized as a key factor underlying the increased risk of metabolic and cardiovascular disease with obesity. Clinical interest in adipocyte-derived extracellular vesicles (Ad-EVs) has intensified due to their potential as circulating biomarkers of adipose tissue health and systemic messengers, regulators and mediators of cardiometabolic health and disease with obesity.

The investigators hypothesize that elevated Ad-EVs in adults with obesity will be negatively associated with endothelium-dependent vasodilation. Furthermore, the investigators hypothesize that in adults with obesity, intentional weight loss-induced reduction in circulating Ad-EVs is associated with greater endothelium-dependent vasodilation.

Being studied: Weight loss without pharmacotherapy

Conditions: Obesity; Weight Loss

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion criteria

  • Age ≥40 years
  • BMI \<25 kg/m2 and BMI >25 kg/m2 for Phase 1 and BMI >25 kg/m2 for Phase 2. Rationale for defining obesity as BMI >25 kg/m2

Exclusion criteria

  • Current smoker
  • Chronic overt medical condition (e.g., evidence of coronary artery disease on resting ECG, any history of myocardial infarction or stroke, or cancer, diabetes based on fasting blood glucose concentration)
  • Alcohol abuse or dependence defined as more than 14 standard drinks/week and no more than 4 standard drinks/day for men and 7 standard drinks/week and 3 standard drinks/day for women (a standard drink is defined as 12 ounces of beer, 5 ounces of wines, 1 ½ ounces of 80-proof distilled spirits) reported during the medical history/physical exam
  • Stage III hypertension (systolic blood pressure >160 mmHg and/or diastolic blood pressure >100 mmHg)
  • Regular vigorous aerobic/endurance exercise (>3 bouts/week, >30 minutes/bout at a workload >6 METS)
  • Women who are pregnant or breastfeeding
  • History of anaphylaxis to betadine, lidocaine, iodine
  • Raynaud's disease
  • History of clotting disorders
  • Anyone taking blood thinners and clotting medications
  • Anyone taking statin medication
  • Planned pregnancy in coming 4-6 months

Recruiting US locations

  • University of Colorado Boulder Clinical and Translational Research Center (CTRC)

    Boulder, CO 80309

    Site contact: Jared Greiner, MS · 303-735-3056 · greinerj@colorado.edu

Study contacts (from the official record)

  • Jared Greiner, MS · 303-735-3605 · greinerj@colorado.edu
All weight loss studies in Colorado →
Adipocyte-Derived Extracellular Vesicles, Weight Loss, and… (NCT06776081) | Bored Studies