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Adolescent Mood During Puberty and Testosterone

University of North Carolina, Chapel Hill · with Foundation of Hope, North Carolina · NCT06072677

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 11–14 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
60
US sites recruiting
1
Study start
August 24, 2023
Record last updated
January 14, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Starting at puberty, female adolescents are nearly three-times more likely to develop internalizing disorders, like depression, while male adolescents are two-times more likely to develop externalizing disorders, like attention deficit hyperactivity disorder (ADHD). This divergence between the sexes during puberty suggests sex-specific pathways of risk and differential effects of sex hormones. The purpose of this research is to determine: 1) sex-specific neural and endocrine features of the pubertal transition that may mediate sex differences in adolescent mood disorders, and 2) the neurophysiological basis of susceptibility to hormone change during puberty.

Being studied: Healthy Minds Program

Conditions: Adolescent Depression

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Between the ages of 11 and 14
  • Have their own personal mobile device and capability to download the MyCap and Healthy Minds apps
  • Experienced a stressful life event within the last year, or endorse moderate depression (defined by a CES-DC score 16 or higher)

Exclusion Criteria

  • Previous experience with the Healthy Minds Program
  • Regular meditation practice
  • Current or history of manic episodes, psychotic symptoms, or current suicidal intent
  • Taking any form of exogenous hormones or intrauterine device (IUD) within one month of participation in the study
  • Taking medications that directly alter cardiovascular or neurological function

Recruiting US locations

  • Carolina Crossing B, Suite 1

    Chapel Hill, NC 27517

    Site contact: Kayla Jensen, BS · 919-445-6815 · nerdlab@unc.edu

Study contacts (from the official record)

  • Kayla Jensen, BS · 919-445-6815 · nerdlab@unc.edu
All mental health studies in North Carolina →
Adolescent Mood During Puberty and Testosterone (NCT06072677) | Bored Studies