Location · North Carolina
Clinical trials recruiting in North Carolina
857 recruiting studies have at least one site in North Carolina; 250 accept healthy volunteers. Studies that need a specific condition are included too, so check each listing.
Want the research companies that run paid Phase 1 studies for healthy volunteers? Paid clinical trial companies in North Carolina.
857 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1Overnight stay mentioned
Nalmefene Implant in Healthy Subjects
ReacX Pharmaceuticals, Inc.
- Location
- Morrisville, NC
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1Overnight stay mentioned
IAP-086-1: A Phase 1 Single Ascending Dose First-Time in Human Study
University of North Carolina, Chapel Hill
- Location
- Chapel Hill, NC + 1 other US site
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteers
Breastfeeding Intervention to Prevent Obesity Among Children
University of North Carolina, Greensboro
- Location
- Greensboro, NC + 1 other US site
- Eligibility basics
- Ages 0 mo+
- RecruitingHealthy volunteersPhase 1/Phase 2
A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease
Novartis Pharmaceuticals
- Location
- Charlotte, NC + 7 other US sites
- Eligibility basics
- Ages 12–55
- RecruitingHealthy volunteersPhase 1/Phase 2
Study of XmAb942 in Healthy Participants and Participants With Ulcerative Colitis
Xencor, Inc.
- Location
- Raleigh, NC + 27 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1
Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics And Pharmacodynamics of SIF001 in Healthy Subjects and in Epilepsy Patients
Suninflam Inc
- Location
- Charlotte, NC + 9 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteersPhase 1/Phase 2
Study of VGA039 in Healthy Volunteers and Patients With Von Willebrand Disease (VIVID)
Vega Therapeutics, Inc
- Location
- Morrisville, NC + 9 other US sites
- Eligibility basics
- Ages 12–60
- RecruitingPhase 1Overnight stay mentioned
A Study of GNTI-122 in Adults Recently Diagnosed With T1D
GentiBio, Inc
- Location
- Chapel Hill, NC + 8 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
pH1N1 Blinded Challenge Study
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Durham, NC + 1 other US site
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
Role of Alpha-to-beta Cell Communication to Adapt Insulin Secretion to Insulin Resistance.
David D'Alessio, M.D.
- Location
- Durham, NC
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersEarly Phase 1
Cardiovascular Effects of Very Low Nicotine Content Cigarettes
Wake Forest University Health Sciences
- Location
- Winston-Salem, NC
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersOvernight stay mentioned
The Osteoarthritis Prevention Study
Wake Forest University
- Location
- Winston-Salem, NC + 1 other US site
- Eligibility basics
- Ages 50+ · Women only
- RecruitingHealthy volunteersEarly Phase 1
Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm
Wake Forest University Health Sciences
- Location
- Winston-Salem, NC
- Eligibility basics
- Ages 22–33
- RecruitingHealthy volunteersPhase 1
Macrophage Regulation of Ozone-Induced Lung Inflammation
Robert Tighe, MD
- Location
- Durham, NC
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking
Duke University
- Location
- Durham, NC
- Eligibility basics
- Ages 18–21
- RecruitingHealthy volunteersPhase 1/Phase 2
Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism
University of North Carolina, Chapel Hill
- Location
- Chapel Hill, NC + 1 other US site
- Eligibility basics
- Ages 18–45
- RecruitingHealthy volunteers
Extensively Hydrolyzed Formula Growth Monitioring Study (GMS)
Mead Johnson Nutrition
- Location
- Wilmington, NC + 9 other US sites
- Eligibility basics
- Ages 0 mo–0 mo
- RecruitingHealthy volunteersPhase 3
A Study to Learn About How a New Pneumococcal Vaccine Works in Infants.
Pfizer
- Location
- Charlotte, NC + 101 other US sites
- Eligibility basics
- Ages 1 mo–7 mo
- RecruitingHealthy volunteersPhase 3
A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)
Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
- Location
- Charlotte, NC + 55 other US sites
- Eligibility basics
- Ages 18–79
- RecruitingHealthy volunteersPhase 2
A Study Assessing Safety, Tolerability, and Efficacy of INNA-051 in Preventing Respiratory Illness Due to Viral Infections in Healthy Adults 18 to 45 Years of Age
ENA Respiratory Pty Ltd
- Location
- Raleigh, NC + 5 other US sites
- Eligibility basics
- Ages 18–45
- RecruitingHealthy volunteersPhase 3
A Phase 3 Study of Revaccination in Subsequent Pregnancies With Bivalent RSV Vaccine and Duration of Protection of a Single Dose
Pfizer
- Location
- Durham, NC + 76 other US sites
- Eligibility basics
- Ages 0 mo+
- RecruitingHealthy volunteersPhase 3
A Study to Assess the Safety, Tolerability, and Immunogenicity of 3 Lots of a Multivalent Pneumococcal Conjugate Vaccine Administered to Adults
Pfizer
- Location
- Wilmington, NC + 36 other US sites
- Eligibility basics
- Ages 18–49
- RecruitingHealthy volunteersPhase 3
Fertilo In Vitro Research Study and Trial
Gameto, Inc.
- Location
- Charlotte, NC + 15 other US sites
- Eligibility basics
- Ages 18–35 · Women only
- RecruitingHealthy volunteers
Observational Study of Decentralized Urine Optical Interaction Patterns Associated With Environmental Microplastic and Nanoplastic Exposure
Ecotera Health LLC
- Location
- Charlotte, NC + 50 other US sites
- Eligibility basics
- Ages 18+