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The Osteoarthritis Prevention Study

Wake Forest University · with National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), Arthritis Foundation · NCT05946044

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 50+ · Women only
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
1230
US sites recruiting
2
Study start
March 21, 2024
Record last updated
July 23, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this study is to establish the efficacy of an intervention of dietary weight loss, exercise, and weight-loss maintenance for knee Osteoarthritis (OA) prevention in adult females aged ≥ 50 years with obesity and no or infrequent knee pain. The primary aim is to compare the effects of a dietary weight loss, exercise, and weight-loss maintenance to an attention control group in preventing the development of structural Magnetic Resonance Imaging (MRI) knee OA. Secondary aims will determine the intervention effects on pain, mobility, health-related quality of life, knee joint compressive forces, inflammatory measures, weight loss, exercise self-efficacy, and cost-effectiveness of this intervention.

Being studied: Diet and Exercise

Conditions: Osteoarthritis, Knee

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Female
  • BMI ≥ 30 kg/m2
  • An eligible knee will have no OA by xray and MRI
  • No or infrequent knee pain (\< 15 days/month) in the same knee

Exclusion Criteria

  • symptomatic or severe coronary artery disease
  • unable to walk without a device
  • blindness
  • type 1 diabetes
  • active treatment for cancer
  • during the past 12 months knee fracture, anterior cruciate ligament (ACL), medial collateral ligament (MCL), or meniscus injury with or without surgical repair
  • knee injection during the past 6 months
  • bilateral knee OA by x-ray Kellgren-Lawrence (KL) ≥ 2
  • bilateral knee OA by MRI
  • bilateral symptomatic knee OA (frequent bilateral knee pain > 15 days per month)
  • BMI\< 30.0 kg/m2
  • male sex
  • claustrophobia
  • contraindication to MRI including body weight > 300 lbs or knee coil does not fit
  • unwillingness or inability to change eating and physical activity habits due to environment
  • cannot speak and read English
  • planning to leave area > 2 months during the 48-month intervention period

Recruiting US locations

  • Brigham and Women's Hospital

    Boston, MA 02115

    Site contact: Paul Oh · 617-525-8349 · paoh@bwh.harvard.edu

  • Wake Forest University

    Winston-Salem, NC 27109

    Site contact: Jovita Newman · 336-758-3969 · jollajk@wfu.edu

Study contacts (from the official record)

  • Jovita Newman · 336-758-3969 · jollajk@wfu.edu
All weight loss studies in Massachusetts →
The Osteoarthritis Prevention Study (NCT05946044) | Bored Studies