Healthy volunteers · North Carolina
Studies for healthy volunteers in North Carolina
250 studies have at least one recruiting site in North Carolina. These studies say in their official record that they accept healthy volunteers. Many are Phase 1 studies that test how a new medicine is absorbed and tolerated; others recruit healthy people as a comparison group alongside patients.
250 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1Overnight stay mentioned
Nalmefene Implant in Healthy Subjects
ReacX Pharmaceuticals, Inc.
- Location
- Morrisville, NC
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 1Overnight stay mentioned
IAP-086-1: A Phase 1 Single Ascending Dose First-Time in Human Study
University of North Carolina, Chapel Hill
- Location
- Chapel Hill, NC + 1 other US site
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteers
Breastfeeding Intervention to Prevent Obesity Among Children
University of North Carolina, Greensboro
- Location
- Greensboro, NC + 1 other US site
- Eligibility basics
- Ages 0 mo+
- RecruitingHealthy volunteersPhase 1/Phase 2
A Phase I/II Study of ITU512 in Healthy Participants and Patients With Sickle Cell Disease
Novartis Pharmaceuticals
- Location
- Charlotte, NC + 7 other US sites
- Eligibility basics
- Ages 12–55
- RecruitingHealthy volunteersPhase 1/Phase 2
Study of XmAb942 in Healthy Participants and Participants With Ulcerative Colitis
Xencor, Inc.
- Location
- Raleigh, NC + 27 other US sites
- Eligibility basics
- Ages 18–75
- RecruitingHealthy volunteersPhase 1
Dose Escalation Study to Assess the Safety, Tolerability, Pharmacokinetics And Pharmacodynamics of SIF001 in Healthy Subjects and in Epilepsy Patients
Suninflam Inc
- Location
- Charlotte, NC + 9 other US sites
- Eligibility basics
- Ages 18–70
- RecruitingHealthy volunteersPhase 1/Phase 2
Study of VGA039 in Healthy Volunteers and Patients With Von Willebrand Disease (VIVID)
Vega Therapeutics, Inc
- Location
- Morrisville, NC + 9 other US sites
- Eligibility basics
- Ages 12–60
- RecruitingHealthy volunteersPhase 1
pH1N1 Blinded Challenge Study
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Durham, NC + 1 other US site
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
Role of Alpha-to-beta Cell Communication to Adapt Insulin Secretion to Insulin Resistance.
David D'Alessio, M.D.
- Location
- Durham, NC
- Eligibility basics
- Ages 18–60
- RecruitingHealthy volunteersEarly Phase 1
Cardiovascular Effects of Very Low Nicotine Content Cigarettes
Wake Forest University Health Sciences
- Location
- Winston-Salem, NC
- Eligibility basics
- Ages 21+
- RecruitingHealthy volunteersOvernight stay mentioned
The Osteoarthritis Prevention Study
Wake Forest University
- Location
- Winston-Salem, NC + 1 other US site
- Eligibility basics
- Ages 50+ · Women only
- RecruitingHealthy volunteersEarly Phase 1
Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm
Wake Forest University Health Sciences
- Location
- Winston-Salem, NC
- Eligibility basics
- Ages 22–33
- RecruitingHealthy volunteersPhase 1
Macrophage Regulation of Ozone-Induced Lung Inflammation
Robert Tighe, MD
- Location
- Durham, NC
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersEarly Phase 1
Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking
Duke University
- Location
- Durham, NC
- Eligibility basics
- Ages 18–21
- RecruitingHealthy volunteersPhase 1/Phase 2
Investigating Whether Acute Elevation of Fatty Acid Levels Alters Cerebral Glucose Transport and Metabolism
University of North Carolina, Chapel Hill
- Location
- Chapel Hill, NC + 1 other US site
- Eligibility basics
- Ages 18–45
- RecruitingHealthy volunteers
Extensively Hydrolyzed Formula Growth Monitioring Study (GMS)
Mead Johnson Nutrition
- Location
- Wilmington, NC + 9 other US sites
- Eligibility basics
- Ages 0 mo–0 mo
- RecruitingHealthy volunteersPhase 3
A Study to Learn About How a New Pneumococcal Vaccine Works in Infants.
Pfizer
- Location
- Charlotte, NC + 101 other US sites
- Eligibility basics
- Ages 1 mo–7 mo
- RecruitingHealthy volunteersPhase 3
A Study of Aleniglipron in Adults With Obesity or Overweight and Type 2 Diabetes Mellitus (ACCOMPLISH-2)
Gasherbrum Bio, Inc., a wholly owned subsidiary of Structure Therapeutics
- Location
- Charlotte, NC + 55 other US sites
- Eligibility basics
- Ages 18–79
- RecruitingHealthy volunteersPhase 2
A Study Assessing Safety, Tolerability, and Efficacy of INNA-051 in Preventing Respiratory Illness Due to Viral Infections in Healthy Adults 18 to 45 Years of Age
ENA Respiratory Pty Ltd
- Location
- Raleigh, NC + 5 other US sites
- Eligibility basics
- Ages 18–45
- RecruitingHealthy volunteersPhase 3
A Phase 3 Study of Revaccination in Subsequent Pregnancies With Bivalent RSV Vaccine and Duration of Protection of a Single Dose
Pfizer
- Location
- Durham, NC + 76 other US sites
- Eligibility basics
- Ages 0 mo+
- RecruitingHealthy volunteersPhase 3
A Study to Assess the Safety, Tolerability, and Immunogenicity of 3 Lots of a Multivalent Pneumococcal Conjugate Vaccine Administered to Adults
Pfizer
- Location
- Wilmington, NC + 36 other US sites
- Eligibility basics
- Ages 18–49
- RecruitingHealthy volunteersPhase 3
Fertilo In Vitro Research Study and Trial
Gameto, Inc.
- Location
- Charlotte, NC + 15 other US sites
- Eligibility basics
- Ages 18–35 · Women only
- RecruitingHealthy volunteers
Observational Study of Decentralized Urine Optical Interaction Patterns Associated With Environmental Microplastic and Nanoplastic Exposure
Ecotera Health LLC
- Location
- Charlotte, NC + 50 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 3
BEATRIX: A Study to Learn About a Group B Streptococcus Vaccine in Healthy Pregnant Women and Their Babies
Pfizer
- Location
- Durham, NC + 111 other US sites
- Eligibility basics
- Ages 0 mo–49
Who these studies look for
“Healthy” is decided at screening, not by you. Sites usually check vital signs, blood and urine tests, an ECG, your medications and sometimes your BMI or smoking status. A study can still turn you away for reasons that have nothing to do with being unwell, such as timing or a full roster.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Do healthy volunteer studies pay?
Many do, because volunteers give up time and follow strict schedules, but amounts are set by each study and are usually only confirmed by the research site. When a record states an amount we show the exact wording; otherwise we say compensation is not disclosed.
What happens at a screening visit?
Expect consent paperwork first, then a health questionnaire, vital signs, blood and urine samples and often an ECG. You can ask questions and withdraw at any time, before or after you sign.