Skip to content
Bored Studies
RecruitingAccepts healthy volunteersPhase 1

Alternation in the Human Microbiome With Commonly Used Topical Medications

University of California, Davis · NCT03437005

View Study & Apply (opens in a new tab)

Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 1
Target enrollment
24
US sites recruiting
1
Study start
January 28, 2013
Record last updated
February 20, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The global aim of this study is to investigate how the human microbiome changes from baseline with commonly used topical medications such as topical antifungals, low to mid potency topical steroids and emollients.

The specific aims are as follows

  • Investigate whether ketoconazole cream, a commonly used topical antifungal, causes alterations in the human skin microbiome with short-term use.
  • Investigate whether desonide 0.05 % ointment, a commonly used low potency topical steroid, alters the human microbiome with short-term use.

Being studied: Desonide 0.05%; Ketoconazole 2%

Conditions: Healthy

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

The inclusion criteria

  • Adults at least 18 years of age.

The exclusion criteria

  • Individuals with known chronically active skin diseases, including atopic dermatitis, psoriasis, seborrheic dermatitis, other autoimmune and inflammatory skin conditions.
  • Patients with a history of skin cancer, multiple nevi, or other isolated lesions will not be excluded.
  • Individuals who have used topical, intravenous, intramuscular, or oral antibiotics within the last 6 months
  • Individuals with known allergies to any of the study medications.
  • Individuals younger than 18 years of age.
  • Adults unable to consent
  • Non-English speaking individuals. Given the complexity in the instructions that subjects will need to follow for proper sample collection, we will not seek to recruit non-English speaking individuals for this pilot study.
  • Prisoners

Recruiting US locations

  • University of California, Davis, Department of Dermatology

    Sacramento, CA 95816

    Site contact: Emanual Maverakis, MD · 916-734-8254 · emaverakis@ucdavis.edu

Study contacts (from the official record)

  • Emanual Maverakis, MD · 916-734-8254 · emaverakis@ucdavis.edu
  • Lauren Downing · 916-551-2635 · ldowning@ucdavis.edu
All healthy volunteers studies in California →
Alternation in the Human Microbiome With Commonly Used Topical… (NCT03437005) | Bored Studies