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RecruitingAccepts healthy volunteersEarly Phase 1

Autonomic Control of the Circulation and VDR

Milton S. Hershey Medical Center · with National Heart, Lung, and Blood Institute (NHLBI) · NCT03513770

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 21–35 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Early Phase 1
Target enrollment
18
US sites recruiting
1
Study start
August 14, 2019
Record last updated
July 9, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The study objective of this project is to examine the mechanisms of the venous distension reflex (VDR) in humans. We hypothesize that COX blockade with ketorolac tromethamine, an intravenous NSAID, will attenuate the muscle sympathetic nerve activity (MSNA) response to limb venous distension. To gain further insight into whether the COX byproducts directly stimulate chemically-sensitive afferents, or enable venodilation and indirectly evoke afferent stimulation, we will measure vein size using 3T MRI during venous distention with and without ketorolac infusions.

Being studied: Wrist-to-elbow (W-E) occlusion; ketorolac tromethamine; saline control

Conditions: Venous Distension Reflex; Blood Pressure

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Are capable of giving informed consent
  • Are any race or ethnicity
  • Are fluent in written and spoken English
  • Have a satisfactory history and physical exam to meet inclusion/exclusion criteria
  • Are free of acute or chronic medical conditions
  • Are 21 - 35 years of age (inclusive)
  • Weigh over 50 kg

Exclusion Criteria

  • Are less than 21 or over 35 years of age
  • Are Pregnant or nursing women
  • Are prisoners or institutionalized individuals or unable to consent
  • Any chronic diseases (hypertension, heart, lung, neuromuscular disease, kidney disease, diabetes or cancer).
  • Are taking medications that may affect their cardiovascular or nervous system
  • Has taken an NSAID within 48 hours of any visit (visit will need to be rescheduled)
  • Has never taken NSAIDs and therefore would not know if they are allergic to it
  • Have a supine BP >140/90 mmHg
  • Have known allergy to ibuprofen-like drugs (NSAIDS) or aspirin
  • Have history of asthma or nasal polyps
  • Have history of GI bleeding or ulcers
  • Subjects with ferromagnetic metal implants
  • Subjects who are claustrophobic

Recruiting US locations

  • Penn State Milton S. Hershey Medical Center

    Hershey, PA 17033

    Site contact: Jian Cui · 7175311799 · jcui@pennstatehealth.psu.edu

All healthy volunteers studies in Pennsylvania →
Autonomic Control of the Circulation and VDR (NCT03513770) | Bored Studies