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RecruitingAccepts healthy volunteersPhase 2

BCAAs in Concussion 3.0

Akiva Cohen · NCT07670195

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 11–23 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 2
Target enrollment
150
US sites recruiting
1
Study start
August 5, 2026
Record last updated
September 3, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This study is a randomized, placebo-controlled, double-blinded, therapeutic exploratory clinical trial of branched chain amino acids (BCAAs) in the treatment of concussion. The aim of the study is to determine whether administration of high-dose BCAAs compared to placebo promotes concussion recovery.

Being studied: BCAA; Placebo

Conditions: Concussion (Diagnosis); MTBI - Mild Traumatic Brain Injury; Concussion, Brain; Concussion

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Males and females,11 - 23 years of age.
  • Weigh at least 40kg.
  • Meeting concussion criteria for the American Congress of Rehabilitative Medicine.

a. One or more clinical signs or two or more acute symptoms with at least one VVE abnormality.

  • Present within 4 days of injury.
  • Post-menarchal females must have a negative urine pregnancy test.
  • Informed consent by the participant, or for participants \<18 years old both informed consent by a parent/guardian and child assent.

Exclusion Criteria

  • Evidence of moderate or severe TBI, including GCS \<13, TBI requiring hospital admission, or TBI requiring neurosurgical intervention.
  • Prior concussion or TBI within 90 days.
  • Known history of maple syrup urine disease or known family history of maple syrup urine disease.
  • Any investigational drug use within 30 days prior to enrollment.
  • Participants who are pregnant, planning on becoming pregnant during the study duration, or breastfeeding.
  • Non-English speaking participants or parent/guardian.

Recruiting US locations

  • Children's Hospital of Philadelphia

    Havertown, PA 19083

    Site contact: Daniel Corwin, MD · 215-327-2306 · corwind@chop.edu

Study contacts (from the official record)

  • Olivia E. Podolak · 8626687645 · podolako@chop.edu
All neurology studies in Pennsylvania →
BCAAs in Concussion 3.0 (NCT07670195) | Bored Studies