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Benefits of Nicotinamide Riboside Upon Cognition and Sleep

State University of New York at Buffalo · NCT05500170

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 65–85 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
50
US sites recruiting
1
Study start
April 4, 2023
Record last updated
September 24, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Poor sleep quality and short sleep duration may be a mechanistic component of cognitive impairment in older adults, associated with a decline in brain-derived neurotrophic factor. Increasing the availability of nicotinamide adenine dinucleotide (NAD+) with supplementation of its precursor, nicotinamide riboside (NR), a form of vitamin B3 may increase the expression of brain-derived neurotrophic factor. This study proposes to examine the benefits of NR supplementation on sleep and cognitive function in older adults with comprehensive subjective and objective measures and to explore its impacts on serum brain-derived neurotrophic factor.

Being studied: Nicotinamide riboside; Placebo

Conditions: Cognitive Impairment; Sleep Quality

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Sleep Quality. Pittsburgh Sleep Quality Index (PSQI) global score >5

Exclusion Criteria

  • Dementia. Veteran Affairs - St. Louis University Mental Status questionnaire (VA-SLUMS) score \<20

Recruiting US locations

  • Buffalo Veteran Affairs Medical Center

    Buffalo, NY 14215

    Site contact: Carleara Weiss, PhD

Study contacts (from the official record)

  • Carleara Weiss, PhD, MS, RN · 7168282006 · carleara@buffalo.edu
  • Rebecca A Lorenz, PhD, RN · 716-829-2204 · rlorenz@buffalo.edu
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Benefits of Nicotinamide Riboside Upon Cognition and Sleep (NCT05500170) | Bored Studies