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Biennial CEM in Women With a Personal History of Breast Cancer

Wendie Berg · with Breast Cancer Research Foundation · NCT06105749

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 30–79 · Women only
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
1600
US sites recruiting
6
Study start
November 8, 2023
Record last updated
August 19, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This is a prospective clinical trial that will examine if biennial contrast-enhanced mammography added to annual 3D mammography (tomosynthesis) substantially improves breast cancer detection with minimal increase in false-positives, in women with a personal history of breast cancer.

Being studied: contrast-enhanced mammography

Conditions: Breast Cancer; Breast Neoplasms; Breast Cancer Female; Neoplasms

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Asymptomatic women, ages 30-79, with a personal history of breast cancer who are at least one year out from any breast cancer surgery and/or treatment and are scheduled to have a routine annual mammogram with tomosynthesis (DBT).

Exclusion Criteria

  • Women with a history of prior moderate or severe iodinated contrast reaction [only those with a prior mild reaction that can be managed by pre-medication AND with and a strong desire to participate will be allowed to participate. However, among these women with a mild sensitivity, if they are allergic to Benadryl (one of the premedications), they will be excluded].
  • Women with implant(s) in the breasts to be screened (as this creates artifacts and diagnostic performance of imaging in women with implants likely does not generalize to those without implants, and the sample size with implants would be too small to infer conclusions.
  • Women who have had bilateral mastectomy
  • Women with a history of kidney failure or estimated glomerular filtration rate (eGFR) \< 30 mL/min
  • Pregnancy or lactation
  • Women actively being treated for cancer of any type with chemotherapy.
  • Women with stage 4 metastasis to visceral areas or brain
  • Women with known personal history of breast cancer who have a screening breast MRI exam within 24 months prior to the current round of CEM.
  • Women with known personal history of breast cancer who had a CEM exam within the prior 23 months

Recruiting US locations

  • UPMC Magee-Womens Imaging - Bethel Park

    Bethel Park, PA 15102

    Site contact: McKenna Rigling, MS · 412-641-8278 · riglingmm@upmc.edu

  • UPMC Magee at the Lemieux Sports Complex

    Cranberry Township, PA 16066

    Site contact: McKenna Rigling, MS · 412-641-8278 · riglingmm@upmc.edu

  • Magee Womancare Monroeville

    Monroeville, PA 15146

    Site contact: McKenna Rigling, MS · 412-641-8278 · riglingmm@upmc.edu

  • Magee-Womens Hospital

    Pittsburgh, PA 15213

    Site contact: McKenna Rigling, MS · 412-641-8278 · riglingmm@upmc.edu

  • Hillman Cancer Center at Shadyside

    Pittsburgh, PA 15232

    Site contact: McKenna Rigling, MS · 412-641-8278 · riglingmm@upmc.edu

  • UPMC West Mifflin Outpatient Center

    West Mifflin, PA 15236

    Site contact: McKenna Rigling, MS · 412-941-8278 · riglingmm@upmc.edu

Study contacts (from the official record)

  • Wendie Berg, MD, PhD · 412-641-8278 · bergwa@upmc.edu
  • McKenna Rigling, MS · 412-641-8278 · riglingmm@upmc.edu
All healthy volunteers studies in Pennsylvania →
Biennial CEM in Women With a Personal History of Breast Cancer (NCT06105749) | Bored Studies