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Biofluid Research on Age-Related or Inherited Neurodegeneration

University of Pennsylvania · with University of Pennsylvania Institute on Aging, National Institute on Aging (NIA) · NCT07798700

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
1000
US sites recruiting
1
Study start
December 12, 2025
Record last updated
September 1, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The aim of this study is to contribute to and continue to sustain a repository of blood samples, nucleic acid (DNA and/or RNA) samples, family history information, and other demographic information from individuals with age-related neurodegenerative conditions, or their family members who may or may not be at risk for similar conditions. This study will continue to further expand research into the molecular and genetic basis of these diseases and their risk factors.

Conditions: Frontotemporal Degeneration (FTD); ALS (Amyotrophic Lateral Sclerosis); Primary Progressive Aphasia (PPA); Familial Frontotemporal Lobar Degeneration (fFTLD); Fronto-temporal Lobar Dementia; Dementia With Lewy Bodies (DLB); Cortical Basal Syndrome (CBS); Alzheimer's Disease (AD); Progressive Supranuclear Palsy(PSP); Parkinson's Disease (PD); Parkinson's Disease Dementia (PDD); Limbic-predominant Age-related TDP-43 Encephalopathy (LATE); Posterior Cortical Atrophy (PCA); Primary Lateral Sclerosis (PLS); Primary Muscular Atrophy (PMA)

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • People with a clinical diagnosis of a neurodegenerative disease including, but not limited to Alzheimer's disease (AD), Parkinson's disease (PD), Parkinson's disease dementia (PDD), dementia with Lewy bodies (DLB), frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), progressive supranuclear palsy (PSP), primary progressive aphasia (PPA), limbic-predominant age-related TDP-43 encephalopathy (LATE), corticobasal syndrome (CBS), posterior cortical atrophy (PCA), primary lateral sclerosis (PLS), primary muscular atrophy (PMA), or individuals with a suspected neurodegenerative dementia and/or movement disorder of unknown etiology will be considered for enrollment
  • Family Members of individuals who meet the criteria of group 1, who are people who may or may not be at risk for a similar neurodegenerative disease, who may or may not be symptomatic, and who may or may not have known or unknown genetic risk.
  • People with no known neurological disease who will provide control data.

Exclusion Criteria

  • Anyone who is under the age of 18.
  • Anyone with a condition or in a situation which, in the investigator's opinion, could confound the study findings or may interfere significantly with a person's participation, including but not limited to neurological, psychological, and other medical conditions (such as cardiac, neurosurgical, infectious conditions).

Recruiting US locations

  • University of Pennsylvania

    Philadelphia, PA 19104

    Site contact: Cara Joyce, MPH · 267-271-0740 · cara.joyce@pennmedicine.upenn.edu

Study contacts (from the official record)

  • Cara Joyce, MPH · 267-271-0740 · cara.joyce@pennmedicine.upenn.edu
  • Emily Xie · 16109553114 · emily.xie@pennmedicine.upenn.edu
All neurology studies in Pennsylvania →
Biofluid Research on Age-Related or Inherited Neurodegeneration (NCT07798700) | Bored Studies