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Biomechanical Precision Medicine Registry for Patients With and Without Heart Failure

Massachusetts General Hospital · with Roche Diagnostics GmbH · NCT03480633

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
3000
US sites recruiting
1
Study start
April 7, 2016
Record last updated
August 31, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

In this single-center, longitudinal observational study, we will comprehensively examine clinical characteristics, proteomic, metabolomic, genomic and imaging data to better understand how different heart failure types may develop and progress over time. We will evaluate distinct sub-groups of heart failure (also known as heart failure phenotypes) and cardiomyopathies including amyloidosis with an ultimate goal of bringing the right medications and therapy to the right patients to optimize benefit and minimized side effects, an effort to improve precision medicine in heart failure.

Conditions: Heart Failure With Normal Ejection Fraction; Heart Failure With Reduced Ejection Fraction; Heart Failure, Right Sided; Heart Failure With Mid Range Ejection Fraction; Cardiovascular Risk Factor

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion criteria for patients with HF

  • 18 years and older
  • History of clinical symptoms consistent with HF and at least one of the following supporting evidence of HF:
  • NT-proBNP > 125 pg/mL
  • BNP > 35 pg/mL
  • Capillary wedge pressure ≥ 15 mmHg on right heart catheterization or CI \<2.8 L/min/m2
  • LVEDP ≥ 15 mmHg
  • Radiographic evidence of pulmonary edema
  • Improvement in symptoms with diuretic initiation of increase
  • CPET evidence of cardiac etiology of symptoms

HFpEF: LVEF ≥ 50% HFrEF: LVEF \<50%

Exclusion criteria (for all patients, including both those with HFpEF and HFrEF):

  • End stage renal disease on dialysis

Recruiting US locations

  • Massachusetts General Hospital

    Boston, MA 02114

    Site contact: Heather Jameson, PhD

Study contacts (from the official record)

  • Abbie Macher, BS · 617-643-6328 · ajmacher@mgh.harvard.edu
  • Laura Stockhausen, BS · 617-724-1339 · lstockhausen@mgh.harvard.edu
All heart & blood pressure studies in Massachusetts →
Biomechanical Precision Medicine Registry for Patients With and… (NCT03480633) | Bored Studies