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Brain Metabolism Observed at 3 Tesla or 7 Tesla in Health and Metabolic Disease

Weill Medical College of Cornell University · with National Institute of Neurological Disorders and Stroke (NINDS) · NCT05085704

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 16–80 · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
20
US sites recruiting
1
Study start
May 3, 2022
Record last updated
June 1, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal is to develop methodology to monitor flux in the citric acid cycle in brain via 13C nuclear magnetic resonance (NMR) spectroscopy at 7 Tesla or 3 Tesla.

Being studied: Magnetic resonance imaging

Conditions: Glut1 Deficiency Syndrome 1; Glucose Metabolism Disorders; Epilepsy; Glut1 Deficiency Syndrome 1, Autosomal Recessive; Glucose Transporter Type 1 Deficiency Syndrome; Glucose Transporter Protein Type 1 Deficiency Syndrome; Glucose Transport Defect

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Subjects will be adolescents or adults, age 16-80 years in good general health (evidenced by normal vital signs and no acute signs or symptoms of illness) or with previously (not for this study) documented G1D (genetically confirmed).
  • Ages 16 to 80
  • Persons with dental fillings, dental crowns, and short (max.4 cm) dental retainer wires can be included.

Exclusion Criteria

  • People or patients with uncontrolled seizure disorder, defined as grand mal (not absence) seizure in the preceding 3 months.
  • Pregnant females will be excluded. A serum or urine pregnancy test will be administered to all females of child bearing potential within 24 hours of administration of the tracer and MRI scan. The pregnancy test will be communicated in person by the study PI. Positive results in subjects 17 years old or younger will be disclosed to parent/guardian only.
  • Subjects with typical implanted orthopedic metal in bone may be considered for inclusion in a 7T scan providing the implant is not within the volume of the radio frequency coil. The PI and the AIRC Medical Director will discuss each case and determine eligibility.
  • Persons with ICD, pacemakers, neurostimulators and other such devices will be excluded.
  • Persons with claustrophobia are excluded.
  • Persons with questionable ferrous implants, bullets, BB's, and shrapnel will be excluded.
  • Subjects who are not fluent in English will be excluded because immediate cooperation and the ability to respond to instructions from the investigators are necessary.
  • People following a ketogenic diet

Recruiting US locations

  • Weill Cornell Medicine

    New York, NY 10065

    Site contact: Rocio Moron Ares, B.S. · 212 746 3278 · rrm4007@med.cornell.edu

Study contacts (from the official record)

  • Juan M Pascual, M.D. · 212 746 3278 · jup9003@med.cornell.edu
  • Rocio Moron Ares, B.S. · 212 746 3278 · rrm4007@med.cornell.edu
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Brain Metabolism Observed at 3 Tesla or 7 Tesla in Health and… (NCT05085704) | Bored Studies