Skip to content
Bored Studies
RecruitingAccepts healthy volunteersPhase 3

Cannabis-Tobacco Co-Use Treatment Study

Medical University of South Carolina · with National Cancer Institute (NCI) · NCT06883162

View Study & Apply (opens in a new tab)

Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 3
Target enrollment
200
US sites recruiting
1
Study start
May 6, 2025
Record last updated
April 3, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The purpose of the RECLAIM study is to evaluate the effectiveness of varenicline (sometimes known as Chantix) compared to placebo (an inactive substance) for the treatment of cigarettes and cannabis (marijuana). Varenicline is not FDA approved for the combination treatment of cigarette abstinence and cannabis reduction or abstinence. All participants will also receive counseling and access to online treatment modules during a quit attempt for cigarettes and a reduction attempt for cannabis. This study is being conducted by the Medical University of South Carolina. All procedures are conducted remotely and there is no in-person visits are needed.

To qualify, participants must be 18 or older, live in South Carolina, use cigarettes and cannabis, and are interested in quitting cigarettes and reducing cannabis.

Being studied: Varenicline; Counseling; Psychosocial modules

Conditions: Tobacco Use Disorder; Tobacco Use Cessation; Cannabis Use; Cannabis Use Disorder; Marijuana Use

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion criteria

  • Ages 18 and over (no upper age limit)
  • Must smoke at least 5 tobacco cigarettes per day on at least 20 out of the past 30 days for the past 3 months
  • Must express interest in quitting tobacco
  • Must express interest in cannabis reduction and/or cessation
  • Must submit a positive instant-read test for cotinine and cannabis prior to enrollment
  • Must self-report cannabis use (THC-dominant products) on at 3 days per week out of the past 30 days
  • Must be willing to take varenicline or placebo for 12 weeks
  • Must reside in South Carolina

Exclusion criteria

  • Any significant or acutely unstable medical, psychiatric, or substance use problem (including clinically significant disorders) that would contraindicate research, interfere with safety, compromise data integrity, or preclude consistent study participation
  • Pregnant or trying to become pregnant
  • Use of medications with smoking cessation efficacy
  • Regular use of e-cigarettes or other tobacco products (\<10 days in the past month)

Recruiting US locations

  • Medical University of South Carolina - Charleston

    Charleston, SC 29403

    Site contact: Elizabeth Chapman · 864-898-2992 · chapmanb@musc.edu

Study contacts (from the official record)

  • Erin Mcclure · 843-792-7192 · mccluree@musc.edu
  • Elizabeth Chapman · 864-898-2992 · chapmanb@musc.edu
All smoking & vaping studies in South Carolina →
Cannabis-Tobacco Co-Use Treatment Study (NCT06883162) | Bored Studies