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Cardiopulmonary Function and Cerebral Blood Flow in Hodgkin Lymphoma Survivors

St. Jude Children's Research Hospital · NCT06421987

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
100
US sites recruiting
1
Study start
May 6, 2024
Record last updated
September 1, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

SURVIVORS

Study participants are being asked to take part in this research study called HODNIRS because the participant is a survivor of Hodgkin Lymphoma (HL) treated with chest radiation and bleomycin at St. Jude Children's Research Hospital. The study is being done to help investigators understand the link between long term effects of chest radiation and bleomycin for HL and brain function in survivors.

Primary Objective To evaluate dynamic changes in CBF and oxygenation during exercise with Near Infrared Spectroscopy (NIRS) in HL survivors and non-cancer controls matched for age, sex, race, and ethnicity. .

Secondary Objectives To examine the degree of CO2 clearance (DLCO/ETCO2) during rest and exercise in Hodgkin Lymphoma (HL) survivors compared to non-cancer controls matched for age, sex, race, and ethnicity.

CONTROLS

Volunteers are being asked to take part in this research study because they are non-first degree relative or friend of someone who received treatment for a childhood cancer or similar illness at St. Jude Children's Research Hospital or are an employee/affiliate of St. Jude Children's Research Hospital and have agreed to be a St. Jude Life Cohort Study (SJLIFE) community control.

Being studied: Near Infrared Spectroscopy (NIRS)

Conditions: Hodgkin Lymphoma, Adult

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

HL Survivors

  • Completed bleomycin and/or thoracic radiation therapy for HL at SJCRH.
  • \<21-years old at diagnosis; currently ≥18-years of age and ≥2-years post therapy.
  • SJLIFE or ACT/SJLIFE participants
  • English language proficiency.

Community Controls

  • SJLIFE control.
  • ≥18-years of age at the time of enrollment with age sampling to broadly match the HL survivors.

Exclusion Criteria

HL Survivors

  • History of cranial or total-body irradiation therapy.
  • History of intrathecal or high dose intravenous antimetabolite therapy.
  • History of head injury or diagnosis of a genetic disorder associated with cognitive impairment.

Recruiting US locations

  • St. Jude Children's Research Hospital

    Memphis, TN 38105

    Site contact: Nicholas Phillips, PhD · 888-226-4343 · referralinfo@stjude.org

Study contacts (from the official record)

  • Nicholas Phillips, PhD · 888-226-4343 · referralinfo@stjude.org
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Cardiopulmonary Function and Cerebral Blood Flow in Hodgkin… (NCT06421987) | Bored Studies