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RecruitingAccepts healthy volunteersPhase 4

Characterization of Humoral and Cellular Immune Responses Elicited by Influenza Vaccination in Healthy Adults

University of Pennsylvania · with National Institute of Allergy and Infectious Diseases (NIAID), Stanford University · NCT05108818

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 4
Target enrollment
700
US sites recruiting
1
Study start
October 7, 2021
Record last updated
February 9, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Cellular and humoral immune responses before and after seasonal influenza vaccination will be assessed. Each year, up to 100 participants will be enrolled. To study age-specific differences in immune responses, participants with various years of birth will be enrolled. The investigators hypothesize that humans with different birth years will mount antibody and cellular responses of different specificities following seasonal influenza vaccination.

Being studied: Seasonal influenza vaccine

Conditions: Influenza, Human

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Provision of signed and dated informed consent form
  • Stated willingness to comply with all study procedures and availability for all study visits
  • Aged 18 years and older
  • In good health based on self-reported medical conditions via an online survey

Exclusion Criteria

  • Known allergic reactions to components of the study vaccine
  • Known latex allergy
  • History of severe reactions following previous immunization with licensed or unlicensed influenza virus vaccines
  • History of GBS within 6 weeks of receipt of a previous influenza vaccine
  • Immunosuppression as a result of an underlying illness or treatment with immunosuppressive or cytotoxic drugs, or use of anticancer chemotherapy or radiation therapy within the preceding 36 months
  • Treatment with immunoglobulin or another blood product within the 3 months prior to enrollment in this study
  • Active neoplastic disease (excluding non-melanoma skin cancer or prostate cancer that is stable in the absence of therapy) or a history of any hematological malignancy ("active" is defined as having received treatment within the past 5 years)
  • Long-term (greater than 2 weeks) usage of oral or parenteral steroids, or high-dose inhaled steroids
  • Administration of an influenza vaccine within 2 months prior to enrollment
  • Known acute or chronic medical condition that, in the opinion of the investigator or appropriate sub-investigator, would render vaccination unsafe or would interfere with the evaluation of responses
  • Participation in a study that involves an experimental agent or having received an experimental agent (other than a COVID-19 vaccine) within 1 month prior to enrollment or expecting to receive another experimental agent during the study period
  • Intends to donate blood during the study period
  • Any condition that would, in the opinion of the site investigator, place the subject at an unacceptable risk of injury or render the subject unable to meet the requirements of the protocol
  • Pregnancy
  • Known human immunodeficiency virus, hepatitis B, or hepatitis C infection
  • Any condition that the principal investigator believes may interfere with successful completion of the study

Recruiting US locations

  • University of Pennsylvania

    Philadelphia, PA 19104

    Site contact: Elizabeth Drapeau, PhD · elizabeth.troisi@pennmedicine.upenn.edu

Study contacts (from the official record)

  • Scott Hensley, PhD · 215-573-3756 · hensley@pennmedicine.upenn.edu
  • Elizabeth Drapeau, PhD · 215-573-3756 · elizabeth.troisi@pennmedicine.upenn.edu
All vaccine studies in Pennsylvania →
Characterization of Humoral and Cellular Immune Responses Elicited… (NCT05108818) | Bored Studies