Vaccine · Pennsylvania
Vaccine studies in Pennsylvania
15 studies have at least one recruiting site in Pennsylvania. Vaccine trials test how well new or updated vaccines produce an immune response and how they are tolerated. Many recruit healthy adults; some focus on older adults, children or people with specific conditions.
15 recruiting studiesSource: ClinicalTrials.gov, refreshed October 26, 2026How we list studies
Studies
- RecruitingHealthy volunteersPhase 1/Phase 2
Phase 1/2 Study of Respiratory Syncytial Virus and Human Metapneumovirus (RSV+HMPV) Vaccine Candidate in Adults 60 Years of Age and Older
Sanofi
- Location
- Philadelphia, PA + 49 other US sites
- Eligibility basics
- Ages 60+
- RecruitingHealthy volunteersPhase 1
Phase 1 Study of CH505 HIV Vaccine Nanoparticles and mRNA Boosters in Healthy Adults
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Pittsburgh, PA + 1 other US site
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 1
Clinical Trial to Evaluate the Safety and Immunogenicity of the V2 Apex-Directed Immunogens DV201P-RNA and DV202B1-RNA in Adult Participants Without HIV
National Institute of Allergy and Infectious Diseases (NIAID)
- Location
- Philadelphia, PA + 6 other US sites
- Eligibility basics
- Ages 18–55
- RecruitingHealthy volunteersPhase 3
A Study to Learn About How a New Pneumococcal Vaccine Works in Infants.
Pfizer
- Location
- Bellevue, PA + 101 other US sites
- Eligibility basics
- Ages 1 mo–7 mo
- RecruitingHealthy volunteersPhase 4
Study of a Recombinant Spike COVID-19 Vaccine With Matrix-M in Older Adults and People at Increased Risk of Severe COVID-19
Sanofi
- Location
- Philadelphia, PA + 19 other US sites
- Eligibility basics
- Ages 12+
- RecruitingHealthy volunteersPhase 3
A Study to Assess the Safety, Tolerability, and Immunogenicity of 3 Lots of a Multivalent Pneumococcal Conjugate Vaccine Administered to Adults
Pfizer
- Location
- Philadelphia, PA + 36 other US sites
- Eligibility basics
- Ages 18–49
- RecruitingHealthy volunteersPhase 3
A Study of COVID-19 Vaccine(s) in Children and Adults
BioNTech SE
- Location
- Philadelphia, PA + 13 other US sites
- Eligibility basics
- Ages 5+
- RecruitingHealthy volunteersPhase 3
A Study to Learn About the Safety of an Expanded Pneumococcal Vaccine in Healthy Infants
Pfizer
- Location
- Sayre, PA + 20 other US sites
- Eligibility basics
- Ages 1 mo–4 mo
- RecruitingHealthy volunteersPhase 2
A Study to Learn About mRNA Vaccines Against Influenza in Adults
Pfizer
- Location
- Philadelphia, PA + 14 other US sites
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 3
A Study to Learn About the Safety, Tolerability, and Immunogenicity of a Fifth Dose of 6-Valent OspA-Based Lyme Disease Vaccine
Pfizer
- Location
- Duncansville, PA + 10 other US sites
- Eligibility basics
- Ages 7+
- RecruitingPhase 3
A Study to Learn About Revaccination With a Vaccine Called RSVpreF in Immunocompromised Adults
Pfizer
- Location
- Duncansville, PA + 12 other US sites
- Eligibility basics
- Ages 18+
- RecruitingPhase 1/Phase 2
Study to Evaluate Safety, Efficacy and Immunogenicity of Acne mRNA Vaccine in Adults With Moderate to Severe Acne
Sanofi Pasteur, a Sanofi Company
- Location
- Camp Hill, PA + 78 other US sites
- Eligibility basics
- Ages 18–45
- RecruitingHealthy volunteers
Optimizing Lymphatic Pumping for Influenza Vaccine Responses in Vulnerable Populations
Lake Erie College of Osteopathic Medicine
- Location
- Erie, PA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteers
Stories to Prevent (StoP) HPV Cancers
Milton S. Hershey Medical Center
- Location
- Hershey, PA
- Eligibility basics
- Ages 18+
- RecruitingHealthy volunteersPhase 4
Characterization of Humoral and Cellular Immune Responses Elicited by Influenza Vaccination in Healthy Adults
University of Pennsylvania
- Location
- Philadelphia, PA
- Eligibility basics
- Ages 18+
Who these studies look for
Vaccine studies often exclude people who recently received a related vaccine or had the infection, and those with conditions or medicines that affect the immune system.
Matching a page like this one never means you qualify. Each research team decides eligibility at screening.
Questions
Could I receive a placebo?
Often yes. Many vaccine trials are randomized, so some participants receive a comparison vaccine or placebo. The consent document explains this.