Cocaine and Pentoxifylline (BED IN 47)

Inclusion Criteria

• able to speak/read English,
• not seeking treatment for drug use at the time of the study,
• female or male between the ages of 18 and 55 years,
• recent smoked or intravenous cocaine use verified by benzoylecgonine positive urine, as well as fulfillment of DSM-5 diagnostic criteria for CUD,
• judged to be medically and psychiatrically healthy by study physicians other than the diagnosis for CUD at the time of screening,
• ECG, read by a cardiologist, within normal limits,
• females using an effective form of birth control and not pregnant or breastfeeding and 8) no known contraindications or allergies to pentoxifylline.

Exclusion Criteria

• unable to speak/read English,
• seeking treatment for drug use,
• under 18 years or over 55 years,
• no recent smoked or intravenous cocaine use as indicated by benzoylecgonine negative urine and no DSM-5 diagnosis of CUD,
• judged to be medically or psychiatrically unhealthy by study physicians at the time of screening,
• ECG, read by a cardiologist, outside normal limits,
• females not using an effective form of birth control or pregnant or breastfeeding,
• contraindications or allergies to pentoxifylline, and
• Self-reported history of head trauma, seizure, CNS tumors, or use of concomitant medications that lower seizure threshold, or first-degree family history of seizures.