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RecruitingAccepts healthy volunteersPhase 1

A Clinical Study of Novel Pneumococcal Vaccine V118C in Children (V118C-002)

Merck Sharp & Dohme LLC · NCT07300267

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 2 mo–1 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Phase 1
Target enrollment
210
US sites recruiting
15
Study start
January 13, 2026
Record last updated
October 2, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Researchers are looking for new vaccines to prevent pneumococcal disease, which is any infection in the lungs or other parts of the body that is caused by a type of bacteria called Streptococcus pneumoniae. V118C is a new vaccine designed to help prevent disease from Streptococcus pneumoniae bacteria.

This study will look at V118C in toddlers and infants. The goal of the study is to learn how safe V118C is for children and how well they tolerate it.

Being studied: V118C (Stage 1); V118C (Stage 2); PCV20 (Stage 1); PCV20 (Stage 2)

Conditions: Pneumococcal Infection

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

The main inclusion criteria include but are not limited to the following:

Stage 1:

  • Is previously vaccinated with 3 routine infant doses of Pneumococcal 20-valent conjugate vaccine (PCV20)
  • Is 12 through 15 months of age

Stage 2:

  • Is approximately 2 months of age

Both Stages

  • Was born at full term (gestational age greater than or equal to 37 weeks)

Exclusion Criteria

The main exclusion criteria include but are not limited to the following:

Stage 1:

  • Has received a PCV dose at 10 months of age and older

Stage 2:

  • Has received prior administration of any pneumococcal vaccine

Both stages

  • Has a history of invasive pneumococcal disease (IPD)
  • Has a known hypersensitivity to any component of V118C or PCV20 including diphtheria toxoid

Recruiting US locations

  • Madera Family Medical Group ( Site 1004)

    Madera, CA 93637

    Site contact: Study Coordinator · 559-673-3000

  • Acevedo Clinical Research Associates ( Site 1029)

    Miami, FL 33142

    Site contact: Study Coordinator · 305-649-8871

  • University of South Florida-Department of Pediatrics ( Site 1002)

    Tampa, FL 33606

    Site contact: Study Coordinator · 813-821-8039

  • Cotton O'Neil Research Center ( Site 1039)

    Topeka, KS 66604

    Site contact: Study Coordinator · 785-354-6000

  • University of Louisville, Norton Children's Research Institute ( Site 1005)

    Louisville, KY 40202

    Site contact: Study Coordinator · 502-629-5820

  • The Pediatric Center ( Site 1025)

    Columbia, MD 21045

    Site contact: Study Coordinator · 443-721-7224

  • Saint Louis University Center for Vaccine Development ( Site 1031)

    St Louis, MO 63104

    Site contact: Study Coordinator · 314-977-6333

  • Child Health Care Associates ( Site 1035)

    East Syracuse, NY 13057

    Site contact: Study Coordinator · 315-652-8800

  • Carolina Family Care ( Site 1021)

    Charleston, SC 29414

    Site contact: Study Coordinator · 843-870-2225

  • Tribe Clinical Research, LLC-Pediatrics ( Site 1008)

    Greenville, SC 29607

    Site contact: Study Coordinator · 864-334-0141

  • Tribe Clinical Research - Spartanburg ( Site 1001)

    Spartanburg, SC 29301

    Site contact: Study Coordinator · 864-334-0141

  • Epic Medical Research - Carrollton ( Site 1038)

    Carrollton, TX 75006

    Site contact: Study Coordinator · 972-777-6956

  • Epic Medical Research- Garland ( Site 1017)

    Garland, TX 75043

    Site contact: Study Coordinator · 972-777-6956

  • University of Texas Medical Branch ( Site 1020)

    League City, TX 77573

    Site contact: Study Coordinator · 832-340-2313

  • Pediatric Research of Charlottesville, LLC ( Site 1012)

    Charlottesville, VA 22902

    Site contact: Study Coordinator · 434-872-9384

Study contacts (from the official record)

  • Toll Free Number · 1-888-577-8839 · Trialsites@msd.com
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