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Cognitive Aftereffects of Neurotoxicity in Children and Young Adults With Relapsed/Refractory Hematologic Malignancies Who Receive CAR T-cell Therapy

National Cancer Institute (NCI) · NCT05237986

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 5+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
60
US sites recruiting
3
Study start
June 23, 2025
Record last updated
October 26, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

Background

CAR T-cell therapy is a promising new treatment for blood cancers. During treatment, a person s T-cells are genetically changed to kill cancer cells. Researchers want to learn more about the effects of potential problems that may be associated with this treatment. We are specifically interested in learning if and how this treatment may affect the brain or your thinking skills.

Objective

To learn if CAR T-cell therapy can affect how children and adults think, process, and remember things.

Eligibility

People aged 5-35 who have blood cancer that has not responded to treatment, or the blood cancer has come back after treatment, and who will receive CAR T-cell therapy. Caregivers are also needed. All participants must be able to speak and read in English or Spanish.

Design

Participants will be screened with a medical history.

Information from participants medical records will be collected.

Participants will take tests at home or at NIH to see how well they think, read, learn, remember, reason, and pay attention. The tests will be both computerized and paper/pencil. They will take less than 1 hour to complete.

Participants and a parent/adult observer will complete a 5-minute Background Information Form and a checklist of nervous system symptoms.

If participants are 5 years or older, they will participate in activities to test their ability to do different thinking tasks, like answer questions, complete puzzle patterns, and remember things.

Participants and their caregivers will complete questions to see if they are having specific symptoms related to receiving CAR T-cells. The questions will assess their well-being and needs. The questions will take less than 1 hour to complete.

Some tests and questions will be repeated at different time points in the study.

Participation will last for up to 3 years.

Conditions: Lymphoma; Leukemia

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria
  • INCLUSION CRITERIA:
  • Participants with disease
  • Participants are diagnosed with relapsed/refractory leukemias or lymphomas, and are scheduled to receive CAR T-cell treatment in one of the enrolling sites
  • For participants enrolled on a CAR T-cell treatment protocol, data sharing for the purposes of this study must be allowed.
  • Age >= 5 and \<=35 years old
  • Participant must have an eligible caregiver (informant) who is willing to complete assessments about the participant of this study
  • Participants (\<18 years, or >=18 years if needed) must have an eligible caregiver to assist with setting up an appropriate test environment for the remote evaluations
  • Participant must be able to speak and understand English or Spanish
  • Participants must have access to a computer or tablet with a camera and an internet connection
  • Participant or parent/guardian must be able to understand and willing to sign a written consent document
  • Caregivers (informants)
  • Participants must be able to speak and read in English or Spanish
  • Participants who are caregivers for participants with disease addressed above
  • Age >= 18 years old
  • Participants must have access to a computer or tablet
  • Participants (of children \<18 years, or >18 years if needed) must be willing to help set up an appropriate test environment for the remote evaluations
  • Participant is able to understand and willing to sign a written consent document

EXCLUSION CRITERIA

-Participants with disease who have a pre-existing global intellectual disability (e.g., Down Syndrome)

Recruiting US locations

  • Children s Hospital of Los Angeles

    Los Angeles, CA 90027

    Site contact: Ashley Whitaker, Ph.D., ABPP-CN · (323) 361-2744 · awhitaker@chla.usc.edu

  • National Institutes of Health Clinical Center

    Bethesda, MD 20892

    Site contact: For more information at the NIH Clinical Center contact National Cancer Institute Referral Office · 888-624-1937

  • Seattle Children s Hospital

    Seattle, WA 98105

    Site contact: Juliane Gust, M.D., Ph.D. · 296-330-7728 · Juliane.Gust@seattlechildrens.org

Study contacts (from the official record)

  • NCI Ped LeukemiaLymph Cell Tx Tm · (240) 760-6970 · ncilltct@mail.nih.gov
  • Pamela L Wolters, Ph.D. · (240) 760-6035 · woltersp@mail.nih.gov
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Cognitive Aftereffects of Neurotoxicity in Children and Young… (NCT05237986) | Bored Studies