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Cognitive and Electrophysiological Assessment of Non-Invasive Temporally-Interfering Electric Fields Stimulation (TIEFS)

University of California, Davis · NCT07663578

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18–65 · All sexes
Healthy volunteers
Accepted
Study type
Interventional · Not applicable
Target enrollment
15
US sites recruiting
1
Study start
April 16, 2025
Record last updated
June 23, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

The goal of this clinical trial is to learn how a non-invasive brain stimulation method called Temporally Interfering Electric Fields Stimulation (TIEFS) affects brain activity and thinking in adults. TIEFS uses electrical currents applied to the scalp to influence brain activity without surgery.

The main questions this study aims to answer are:

  • How does TIEFS change brain signals measured with brain recordings?
  • Does TIEFS affect thinking abilities such as memory, language, movement, or perception?
  • Is TIEFS safe and well tolerated when used in people?

This study includes two groups of participants. One group includes adults with epilepsy who are already undergoing specialized brain monitoring as part of their medical care. The other group includes healthy adults with no history of seizures.

Participants will

  • Receive brief sessions of TIEFS using electrodes placed on the scalp
  • Complete computer-based tasks that test memory, attention, language, or movement. Answer questions about how the stimulation feels
  • Have brain activity recorded during the study

Each study visit lasts up to three hours and may occur in one or two sessions. Information from this study may help researchers better understand the human brain and support the development of future non-invasive brain stimulation treatments.

Being studied: Temporal Interference Electrical Stimulation

Conditions: Epilepsy

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

Inclusion Criteria

  • Adult patients (age 18-65 years of age) undergoing an intracerebral electrophysiology study for epilepsy pre-surgical evaluation are eligible for inclusion.
  • For healthy control subjects are also eligible for inclusion (Scalp EEG measurements).
  • Participants must be able to sufficiently speak and understand English or Spanish for consent and be able to understand and complete cognitive tasks.
  • All subjects must have the ability to give valid informed consent.

Exclusion Criteria

  • No pregnant women will be recruited.
  • People with implanted electrical devices such as Deep Brain Stimulation devices or Pacemakers.
  • No prisoners will be recruited.

Recruiting US locations

  • University of California Davis Medical Center

    Sacramento, CA 95817

    Site contact: Nigel P Pedersen, MBBS · 617-462-8120 · nppedersen@health.ucdavis.edu

Study contacts (from the official record)

  • Nigel P Pedersen, MBBS · 617-462-8120 · nppedersen@health.ucdavis.edu
  • Raul S Castillo-Astorga, MD · 530-220-0057 · rcastilloastorga@ucdavis.edu
All neurology studies in California →
Cognitive and Electrophysiological Assessment of Non-Invasive… (NCT07663578) | Bored Studies