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Cognitive Decline Following Deep Brain Stimulation

Medical University of South Carolina · NCT05822388

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Opens the official ClinicalTrials.gov record, with the study team’s contacts. Bored Studies doesn’t enroll anyone.

Key facts

Compensation
Not posted. Ask the study team before screening.
Who can join
Ages 18+ · All sexes
Healthy volunteers
Accepted
Study type
Observational
Target enrollment
80
US sites recruiting
1
Study start
April 1, 2023
Record last updated
May 29, 2026

Status re-checked against ClinicalTrials.gov within the last 12 hours.

What the study is about

This research study aims to identify MRI-based brain biomarkers that predict an individual's response to Deep Brain Stimulation (DBS). In particular, this study will focus on changes in cognition associated with DBS. A total of 55 participants with Parkinson's Disease planning to undergo DBS will be recruited from MUSCs Clinical DBS Program. Participants will undergo four visits, including a 1-hour screening visit, a 1.5-hour pre-DBS MRI scanning visit, and a 3.5-hour post-DBS cognitive assessment visit. In addition control participants without Parkinson's Disease will be recruited to undergo MRI scanning and cognitive assessments.

Being studied: Deep Brain Stimulation Surgical Procedures as Part of Routine Clinical Care

Conditions: Parkinson Disease; Movement Disorders

Eligibility criteria

Copied from the official record. The study team makes the final decision at screening.

Show full criteria

PD Participants

Inclusion Criteria

  • Subjects above 18 years of age
  • Subjects who will undergo DBS surgery as part of their clinical care for PD

Exclusion Criteria

  • Uncorrected visual or hearing impairments, as indicated by self-report
  • Individuals who are pregnant or expect to become pregnant during the course of the study
  • Individuals with claustrophobia, or the inability to lie supine position in the MRI scanner
  • COPD with oxygen dependence
  • Non-MRI compatible metal implants (surgical clips or staples, cardiac pacemakers etc.)

Non-PD Control Participants

Inclusion Criteria

  • Subjects above 18 years of age
  • Age matched to participants in PD group

Exclusion Criteria

  • Diagnosis of Parkinsons Disease or other movement disorder
  • Untreated neuropsychiatric disorders
  • Uncorrected visual or hearing impairments, as indicated by self-report
  • Individuals who are pregnant or expect to become pregnant during the course of the study
  • Individuals with claustrophobia, or the inability to lie supine position in the MRI scanner
  • COPD with oxygen dependence
  • Non-MRI compatible metal implants (surgical clips or staples, cardiac pacemakers etc.)

Recruiting US locations

  • Medical University of South Carolina

    Charleston, SC 29425

    Site contact: Daniel H Lench, PhD · 843-792-9115 · lenchd@musc.edu

Study contacts (from the official record)

  • Daniel H Lench, PhD · 843-792-9115 · lenchd@musc.edu
  • Gonzalo J Revuelta, DO · 843-792-7262 · revuelta@musc.edu
All neurology studies in South Carolina →
Cognitive Decline Following Deep Brain Stimulation (NCT05822388) | Bored Studies